IP6 (Inosital 1,2,3,4,5,6-hexakisphosphate) / β-catenin/ZEB1 Cancer Research Results

IP6, IP6 (Inosital 1,2,3,4,5,6-hexakisphosphate): Click to Expand ⟱

Features:

Vitamin like substance. Found in cereals, nuts and legumes.
Inositol hexaphosphate (IP6) is a dietary component that constitutes approximately 1 to 5% of the weight of most cereals, nuts, oil seeds, legumes, and grains [1, 2]. In particular, approximately 9.5 to 14.5% of the weight of rice bran is composed of IP6.

• Antioxidant Activity
– IP6 can chelate metal ions and scavenge free radicals, thereby reducing oxidative stress and preventing DNA damage that could initiate or promote cancer.

• Modulation of Signal Transduction Pathways
– IP6 influences key pathways such as PI3K/Akt and MAPK, which are involved in cell survival, growth, and proliferation. Its modulation can lead to reduced cell proliferation and enhanced apoptotic signaling.

• Induction of Apoptosis
– By activating pro-apoptotic factors and suppressing anti-apoptotic proteins, IP6 promotes programmed cell death in cancer cells.

• Cell Cycle Arrest
– IP6 has been shown to interfere with cell cycle progression, particularly by regulating cyclin-dependent kinases. This arrest can prevent the rapid and uncontrolled division of cancer cells.

• Promotion of Cell Differentiation
– IP6 may encourage malignant cells to differentiate into more normal cell types, which typically have reduced proliferative abilities and lower tumorigenic potential.

• Inhibition of Angiogenesis
– By disrupting the signals needed for new blood vessel formation, IP6 can limit the tumor’s blood supply, thereby restricting tumor growth and metastasis.

• Immune Modulation
– Some studies suggest that IP6 may enhance the immune response against tumors, contributing to its overall anti-cancer activity.

β-catenin/ZEB1, β-catenin/ZEB1: Click to Expand ⟱

Source: HalifaxProj (inactivate)

Type:

β-catenin and ZEB1 are two important proteins that play significant roles in cancer biology, particularly in the processes of cell adhesion, epithelial-mesenchymal transition (EMT), and tumor progression.
β-catenin is a key component of the Wnt signaling pathway, which is crucial for cell proliferation, differentiation, and survival. It also plays a role in cell-cell adhesion by linking cadherins to the actin cytoskeleton.
Role in Cancer: ZEB1 is often upregulated in cancer and is associated with increased invasiveness and metastasis. It can repress epithelial markers (like E-cadherin) and promote mesenchymal markers (like N-cadherin and vimentin), facilitating the transition to a more aggressive cancer phenotype.

(MMP)-2 and MMP-9, which are the down-stream targets of β-catenin and play a crucial role in cancer cell metastasis.

Scientific Papers found: Click to Expand⟱

1088-

IP6,

Preventive Inositol Hexaphosphate Extracted from Rice Bran Inhibits Colorectal Cancer through Involvement of Wnt/β-Catenin and COX-2 Pathways

in-vivo,

CRC,

rats

AntiTum↑, β-catenin/ZEB1↓, COX2↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Migration ⓘ

β-catenin/ZEB1↓, 1,

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,

Functional Outcomes ⓘ

AntiTum↑, 1,
Total Targets: 3

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: β-catenin/ZEB1, β-catenin/ZEB1

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells