Lactobacillus / HSP90 Cancer Research Results

LA, Lactobacillus: Click to Expand ⟱
Features: Bacteria
Lactobacillus acidophilus: Gram-positive, homofermentative, anaerobic microbe
Lactobacillus johnsonii: probiotic bacteria found in the human body and fermented foods.
Lactobacillus Plantarum: probiotic bacterium that may help with inflammation, blood sugar

Lactobacillus crispatus
Lactobacillus rhamnosus
HSP90, HSP90: Click to Expand ⟱
Source: HalifaxProj(inhibit)
Type:
Heat shock protein 90 (Hsp90) is a molecular chaperone that plays a critical role in the proper folding, stabilization, and function of many proteins, including those involved in cell signaling, cell cycle regulation, and stress responses.
-Hsp90 interacts with a variety of client proteins that are often mutated or overexpressed in cancer. These include oncogenes (like HER2, BRAF, and AKT) and tumor suppressor proteins (like p53).
-Hsp90 is often overexpressed in cancer cells, which can help them survive under stressful conditions, such as those found in the tumor microenvironment. This overexpression is associated with poor prognosis in several types of cancer.
-HSPs, particularly HSP90, are known to stabilize many proteins that drive cancer progression (oncoproteins).
Scientific Papers found: Click to Expand⟱
1243- LA,    Lactobacilli Modulate Hypoxia-Inducible Factor (HIF)-1 Regulatory Pathway in Triple Negative Breast Cancer Cell Line
- in-vitro, BC, MDA-MB-231
Hif1a↓, HSP90↓, GLUT1↓, VHL↓, SHARP↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

SHARP↑, 1,  

Protein Folding & ER Stress ⓘ

HSP90↓, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1,   VHL↓, 1,  

Barriers & Transport ⓘ

GLUT1↓, 1,  
Total Targets: 5

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: HSP90, HSP90
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:108  Target#:149  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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