Licorice / LOX1 Cancer Research Results

LE, Licorice: Click to Expand ⟱
Features:
Glycyrrhizic acid (GA) is a significant constituent of licorice root.
Glycyrrhizin, the main active component obtained from licorice roots, has many pharmacological and biological functions such as protecting liver cells, anti-inflammation, anti-virus, immunomodulation, has been widely applied in the treatment of clinically related hepatic diseases (Dastagir & Rizvi, 2016). Glycyrrhizin is a natural inhibitor of HMGB1
LOX1, Lectin-like oxidized low-density lipoprotein receptor 1: Click to Expand ⟱
Source:
Type:
LOX-1 (Lectin-like oxidized low-density lipoprotein receptor 1) is a protein that has been implicated in various diseases, including cancer. Research has shown that LOX-1 is overexpressed in several types of cancer, including breast, lung, colon, and prostate cancer.

LOX-1 is involved in the regulation of cell proliferation, apoptosis (cell death), and angiogenesis (the formation of new blood vessels). In cancer, LOX-1 can promote tumor growth and metastasis by:

Enhancing cell proliferation and survival
Inhibiting apoptosis
Promoting angiogenesis
Facilitating the migration and invasion of cancer cells
Studies have also shown that LOX-1 can interact with other molecules involved in cancer progression, such as vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs).

Inhibiting LOX-1 has been proposed as a potential therapeutic strategy for cancer treatment.
Scientific Papers found: Click to Expand⟱
1787- LE,    Licorice and cancer
- Review, Var, NA
Inflam↓, AntiCan↓, DNAdam↓, LOX1↓, COX2↓, PKCδ↓, EGFR↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


DNA Damage & Repair ⓘ

DNAdam↓, 1,  

Migration ⓘ

PKCδ↓, 1,  

Angiogenesis & Vasculature ⓘ

EGFR↓, 1,   LOX1↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   Inflam↓, 1,  

Clinical Biomarkers ⓘ

EGFR↓, 1,  

Functional Outcomes ⓘ

AntiCan↓, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: LOX1, Lectin-like oxidized low-density lipoprotein receptor 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:115  Target#:680  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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