Pterostilbene / PKA Cancer Research Results

PTS, Pterostilbene: Click to Expand ⟱

Features:

Antioxidant found in blueberries, cranberries and grapes.
Pterostilbene (trans-3,5-dimethoxy-40-hydroxystilbene) is a naturally occurring stilbene, found mainly in blueberries and grapes. It is a dimethylated derivative of resveratrol with comparable antioxidant, anti-inflammatory and anticarcinogenic properties [26].
-more bioavailable than resveratrol
-Antioxidant activity: Reduces reactive oxygen species and lipid peroxidation
-Anti-inflammatory: Downregulates pro-inflammatory cytokines- IL-1β, TNF-α, NF-κB
-Amyloid pathology:inhibits Aβ aggregation and promotes clearance- Aβ, APP, BACE1
-Reduces hyperphosphorylation of tau protein
-Inhibits histone deacetylases (HDACs)
-Increases acetylcholine by inhibiting acetylcholinesterase
-Sirtuin activation

Rank	Pathway / Axis	Cancer Cells	Normal Cells	Label	Primary Interpretation	Notes
1	SIRT1 / AMPK metabolic sensing	↑ AMPK; context-dependent SIRT1 modulation	↑ SIRT1 / ↑ AMPK	Driver	Energy-stress signaling	Pterostilbene strongly engages energy-sensing pathways due to high bioavailability
2	PI3K → AKT → mTOR axis	↓ AKT / ↓ mTOR	↔ adaptive suppression	Driver	Growth and survival inhibition	AKT/mTOR suppression explains cytostatic and pro-apoptotic effects in cancer cells
3	Reactive oxygen species (ROS)	↑ ROS (mild, dose-dependent)	↓ ROS / buffered	Conditional Driver	Biphasic redox modulation	More balanced redox profile than resveratrol; weaker pro-oxidant behavior
4	Mitochondrial integrity / intrinsic apoptosis	↓ ΔΨm; ↑ caspase activation	↔ preserved	Secondary	Execution of apoptosis	Mitochondrial apoptosis follows metabolic and redox stress
5	NF-κB signaling	↓ NF-κB activation	↓ inflammatory NF-κB tone	Secondary	Suppression of inflammatory survival programs	NF-κB inhibition contributes to anti-invasive and chemosensitizing effects
6	Cell cycle regulation	↑ G1 or G2/M arrest	↔ spared	Phenotypic	Cytostatic growth control	Cell-cycle arrest reflects upstream metabolic and signaling effects
7	NRF2 antioxidant response	↑ NRF2 (adaptive)	↑ NRF2 (protective)	Adaptive	Redox compensation	NRF2 activation contributes to stress buffering rather than primary cytotoxicity

PKA, protein kinase A: Click to Expand ⟱

Source:

Type:

Protein kinase A (PKA)
• PKA is composed of regulatory (R) and catalytic (C) subunits. Binding of cAMP to the regulatory subunits releases the catalytic subunits, which then phosphorylate target proteins.
– Increased PKA activity has been associated with the activation of downstream signaling pathways that promote cell growth and survival.
– Thus, the level of PKA activation (often indirectly inferred by phosphorylation status of downstream targets) can serve as a marker for tumor progression and treatment resistance.
– PKA does not act in isolation—it interacts with other signaling pathways (e.g., MAPK, PI3K/AKT).

Scientific Papers found: Click to Expand⟱

2408-

PTS,

Pterostilbene suppresses the growth of esophageal squamous cell carcinoma by inhibiting glycolysis and PKM2/STAT3/c-MYC signaling pathway

in-vitro,

ESCC,

TumCP↓, TumCMig↓, PKA↓, GlucoseCon↓, lactateProd↓, PKM2↓, STAT3↓, cMyc↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Core Metabolism/Glycolysis ⓘ

cMyc↓, 1, GlucoseCon↓, 1, lactateProd↓, 1, PKM2↓, 1,

Proliferation, Differentiation & Cell State ⓘ

STAT3↓, 1,

Migration ⓘ

PKA↓, 1, TumCMig↓, 1, TumCP↓, 1,
Total Targets: 8

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: PKA, protein kinase A

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells