Vitamin B12 / Hcy/homoC Cancer Research Results

VitB12, Vitamin B12: Click to Expand ⟱

Features:

Vitamin B12 = cobalamin (water-soluble vitamin; forms: methylcobalamin, adenosylcobalamin, cyanocobalamin, hydroxocobalamin). Sources: animal-derived foods; requires intrinsic factor–mediated absorption; transport via transcobalamin (TCII). Primary mechanisms (ranked):
1) Methionine synthase cofactor → homocysteine → methionine → SAM → DNA/RNA/histone methylation (one-carbon metabolism integration).
2) Methylmalonyl-CoA mutase cofactor → odd-chain FA / branched-chain AA metabolism; mitochondrial anaplerosis support.
3) Genome stability support (via nucleotide synthesis + methylation balance).
Bioavailability/PK relevance: Active absorption saturable (~1–2 µg/meal via IF); passive diffusion at high oral doses (~1%); serum levels tightly regulated; intracellular utilization depends on TCII uptake and lysosomal processing.
In-vitro vs oral exposure: Most cancer cell studies use supraphysiologic cobalamin or manipulate one-carbon flux; effects typically reflect methylation / nucleotide synthesis dependency rather than direct cytotoxicity.
Clinical evidence status: Essential nutrient; deficiency correction clearly beneficial; no established anticancer efficacy; epidemiology mixed (very high serum B12 sometimes correlates with cancer presence—likely reverse causality/biomarker phenomenon rather than causation).

Helps make red blood cells, metabolize food and prevent nerve damage.

Vitamin B12 (Cobalamin) — Cancer vs Normal Pathway Effects

Rank	Pathway / Axis	Cancer Cells (↑ / ↓ / ↔)	Normal Cells (↑ / ↓ / ↔)	TSF	Primary Effect	Notes / Interpretation
1	One-carbon metabolism (Methionine synthase → SAM)	↑ methylation capacity; ↑ nucleotide synthesis (proliferation support)	↑ genome stability; ↑ normal DNA synthesis	R→G	Methyl donor cycling	Supports SAM production; in rapidly dividing tumors may facilitate growth if not limiting.
2	DNA methylation / Epigenetics	↔ / ↑ (context-dependent; can restore normal methylation if deficient)	↑ methylation homeostasis	G	Epigenetic stability	Deficiency → hypomethylation/genomic instability; supplementation restores baseline rather than inducing supraphysiologic hypermethylation in most settings.
3	Nucleotide synthesis (via folate cycle coupling)	↑ proliferation support (if B12 limiting)	↑ normal hematopoiesis	R→G	DNA replication capacity	Mechanistically linked to folate; deficiency leads to megaloblastic anemia.
4	Mitochondrial metabolism (Methylmalonyl-CoA mutase)	↔ (supports baseline metabolism)	↑ mitochondrial function	R	Anaplerotic support	Prevents methylmalonic acid accumulation; preserves mitochondrial efficiency.
5	ROS	↔ (indirect)	↓ oxidative stress (deficiency correction)	R	Redox balance (secondary)	Effects mediated through improved mitochondrial and methylation balance.
6	NRF2	↔ (no direct axis)	↔	G	Adaptive response (indirect)	No primary NRF2-targeting activity established.
7	Ca²⁺	↔	↔	P	Not a core pathway	No meaningful Ca²⁺ modulation axis.
8	HIF-1α / Warburg	↔ (indirect via proliferation capacity)	↔	G	Metabolic permissiveness	No direct hypoxia pathway targeting; effects are permissive rather than suppressive.
9	Ferroptosis	↔	↔	R	Not established	No defined ferroptotic mechanism.
10	Clinical Translation Constraint	Essential nutrient; correction of deficiency critical. No validated anticancer benefit; very high serum B12 often reflects disease state rather than supplementation causality.		—	Evidence	Interpret epidemiologic associations cautiously (reverse causation common).

TSF legend: P: 0–30 min | R: 30 min–3 hr | G: >3 hr

Hcy/homoC, homocysteine: Click to Expand ⟱

Source:

Type: Biomarker

Homocysteine is a sulfur-containing amino acid produced during the metabolism of methionine. Elevated homocysteine levels and alterations in its metabolic enzymes have been associated with various pathological processes, including oxidative stress, DNA damage, and inflammation.
-Elevated plasma homocysteine levels (hyperhomocysteinemia) are a well‐established risk factor for cardiovascular diseases.
-Some studies have suggested that high levels of homocysteine might be associated with an increased risk of certain cancers.
-Vitamins like folate, B6, and B12 are key regulators of homocysteine metabolism, some research has examined whether supplementation might modulate cancer risk. However, clinical outcomes have been mixed and further research is needed.

-Various clinical trials have shown that the oral supplementation of folic acid, B6, and B12 vitamins significantly lowers circulating homocysteine levels.

Scientific Papers found: Click to Expand⟱

4061-

betaCar,

VitB12,

VitB6,

FA,

VitB3

Revisiting the Role of Vitamins and Minerals in Alzheimer’s Disease

Review,

AD,

*cognitive↑, *cognitive↑, *Inflam↓, *Hcy/homoC↓, *TNF-α↓, *other↝, *memory↑,

2175-

Chemo,

VitB12,

FA,

Systemic Chemotherapy Interferes in Homocysteine Metabolism in Breast Cancer Patients

Study,

BC,

other↓, other↝, Hcy/homoC↓, eff↝, other↝,

4261-

Chol,

VitB12,

FA,

VitB2,

B-Vitamin and Choline Supplementation Changes the Ischemic Brain

Study,

Stroke,

*BDNF↑, *Hcy/homoC↓,

2174-

FA,

VitB12,

Analysis,

Var,

Hcy/homoC↓, eff↑, eff↑, eff↑, eff↝, Hcy/homoC↝, other?,

6961-

FA,

VitB12,

VitB6,

Silicon,

Alum

B Vitamins Prevent Iron-Associated Brain Atrophy and Domain-Specific Effects of Iron, Copper, Aluminum, and Silicon on Cognition in Mild Cognitive Impairment

Trial,

AD,

daily folic acid (0.8 mg)/vitamin B12 (0.5 mg)/vitamin B6 (20 mg) (n = 133) or placebo for two years.

n = 266, 77.6-year-old, 60.7% female

*BrainVol↝, *cognitive↝, *cognitive↑, *Dose↝, *other↝, *Hcy/homoC↓, *Risk↓, *BrainVol∅, *BrainVol↑, *other↝, *cognitive↑, *cognitive↑, *other↝, *Risk↝,

6956-

FA,

VitB12,

A randomized placebo-controlled trial of using B vitamins to prevent cognitive decline in older mild cognitive impairment patients

Trial,

AD,

 279 MCI outpatients aged ≥65 years

*Dose↝, *Hcy/homoC↓, *cognitive↑, *eff↓,

6949-

FA,

VitB12,

A controlled trial of homocysteine lowering and cognitive performance

Trial,

AD,

276 healthy participants, 65 years of age or older, with plasma homocysteine concentrations of at least 13 micromol per liter

*Hcy/homoC↓, *cognitive∅,

6948-

FA,

VitB12,

A randomized placebo controlled trial of homocysteine lowering to reduce cognitive decline in older demented people

Trial,

AD,

*Dose↝, *Hcy/homoC↓, *cognitive∅,

4074-

FA,

VitB12,

Associations between Alzheimer's disease and blood homocysteine, vitamin B12, and folate: a case-control study

Trial,

AD,

 115 patients with AD and 115 matched controls.

*cognitive↑, *Hcy/homoC↓, *other↝, *other↝,

4064-

FA,

VitB6,

VitB12,

High-dose B vitamin supplementation and cognitive decline in Alzheimer disease: a randomized controlled trial

Trial,

AD,

folate 5mg, vitamin B6 25mg, vitamin B12 1 mg

409 participants

*Hcy/homoC↓, *cognitive∅,

2173-

FA,

VitB12,

Elevated serum homocysteine levels associated with poor recurrence-free and overall survival in patients with colorectal cancer

Study,

CRC,

Risk↓, eff↝, eff↝, Hcy/homoC↓,

2176-

FA,

VitB12,

Hyperhomocysteinemia and Cancer: The Role of Natural Products and Nutritional Interventions

Review,

Var,

Hcy/homoC↓, eff↝,

4063-

Flav,

VitB12,

VitB6,

Homocysteine and Dementia: An International Consensus Statement

Review,

AD,

*Hcy/homoC↓, *cognitive↑,

4318-

VitB12,

Unraveling the molecular mechanisms of vitamin deficiency in Alzheimer's disease pathophysiology

Review,

AD,

*Hcy/homoC↓, *cognitive↑,

4043-

VitB12,

FA,

Preventing Alzheimer's disease-related gray matter atrophy by B-vitamin treatment

Trial,

AD,

folic acid 0.8 mg/d, vitamin B12 0.5 mg/d, vitamin B6 20 mg/d) on elderly volunteers with memory complaint

*other↑, *other↑, *eff↝, *Hcy/homoC↓, *cognitive↑,

4045-

VitB12,

FA,

Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial

Trial,

AD,

0.8 mg folic acid, 0.5 mg vitamin B(12) and 20 mg vitamin B(6) (133 participants)

*Hcy/homoC↓, *cognitive↑, *memory↑, *other↑,

4058-

VitB12,

VitB6,

FA,

The preventive efficacy of vitamin B supplements on the cognitive decline of elderly adults: a systematic review and meta-analysis

Review,

AD,

*Hcy/homoC↓, *cognitive↑,

4054-

VitB12,

VitB6,

FA,

Role of B vitamins in modulating homocysteine and metabolic pathways linked to brain atrophy: Metabolomics insights from the VITACOG trial

Study,

AD,

 89 B vitamin–treated and 84 placebo-treated MCI participants over a 2 year follow-up period.

*Hcy/homoC↓, *neuroP↑, *cognitive↑,

4053-

VitB12,

VitB6,

FA,

Vitamins in Alzheimer’s Disease—Review of the Latest Reports

Review,

AD,

*cognitive↑, *Hcy/homoC↓, *SAM-e↓,

4048-

VitB12,

Plasma Homocysteine and Serum Folate and Vitamin B12 Levels in Mild Cognitive Impairment and Alzheimer’s Disease: A Case-Control Study

Study,

AD,

112 subjects with MCI, 89 AD patients and 115 healthy controls.

*Hcy/homoC↓, *other↝, *other↝,

4077-

VitB6,

FA,

VitB12,

VitD3,

VitE

Vitamin Supplementation as an Adjuvant Treatment for Alzheimer’s Disease

Review,

AD,

*antiOx↑, *cognitive↑, *Hcy/homoC↓, *Risk↓, *Risk↓, *Risk↓, *other↝, *Dose↝, *Risk↓, *Risk↓,

Showing Research Papers: 1 to 21 of 21

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 21

Pathway results for Effect on Cancer / Diseased Cells:

Functional Outcomes(tgid=23) ⓘ

Risk↓, 1,
Total Targets: 8

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1, SAM-e↓, 1,

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 3, other↝, 9,

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1, TNF-α↓, 1,

Synaptic & Neurotransmission(tgid=18) ⓘ

BDNF↑, 1, BrainVol↑, 1, BrainVol↝, 1, BrainVol∅, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 4, eff↓, 1, eff↝, 1,

Clinical Biomarkers(tgid=22) ⓘ

Hcy/homoC↓, 17,

Functional Outcomes(tgid=23) ⓘ

cognitive↑, 15, cognitive↝, 1, cognitive∅, 3, memory↑, 2, neuroP↑, 1, Risk↓, 6, Risk↝, 1,
Total Targets: 21

Scientific Paper Hit Count for: Hcy/homoC, homocysteine

21 Vitamin B12
18 Folic Acid, Vit B9
8 Vitamin B6,pyridoxine
1 beta-carotene(VitA)
1 Vitamin B3,Niacin
1 Chemotherapy
1 Choline
1 Vitamin B2,Riboflavin
1 Silicic Acid
1 Aluminum
1 flavonoids
1 Vitamin D3
1 Vitamin E

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:165  Target#:1257  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

Vitamin B12 / Hcy/homoC Cancer Research Results

Vitamin B12 (Cobalamin) — Cancer vs Normal Pathway Effects

Pathway results for Effect on Cancer / Diseased Cells:

Transcription & Epigenetics(tgid=7) ⓘ

Drug Metabolism & Resistance(tgid=21) ⓘ

Clinical Biomarkers(tgid=22) ⓘ

Functional Outcomes(tgid=23) ⓘ

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

Transcription & Epigenetics(tgid=7) ⓘ

Immune & Inflammatory Signaling(tgid=16) ⓘ

Synaptic & Neurotransmission(tgid=18) ⓘ

Drug Metabolism & Resistance(tgid=21) ⓘ

Clinical Biomarkers(tgid=22) ⓘ

Functional Outcomes(tgid=23) ⓘ

Home Page