Vitamin K2 / ECM/TCF Cancer Research Results

VitK2, Vitamin K2: Click to Expand ⟱
Features:
Vitamin K2 (menaquinone)
Menaquinone-4 (MK-4), a subtype of vitamin K2 Helps blood clot, calcium metabolise and heart health.
Bone health: Vitamin K2 helps to regulate calcium levels in the body, which can help to prevent conditions such as osteoporosis and fractures.
Vitamin K2 has been studied for its potential role in cancer prevention and treatment. Some of the key findings include:
-Shown to inhibit the growth of cancer cells, including those found in leukemia, lung cancer, and prostate cancer.
-Shown to induce apoptosis (cell death) in cancer cells, which can help to prevent the spread of cancer.
-Shown to have anti-angiogenic effects, which means it can help to prevent the formation of new blood vessels that feed cancer cells.
-Synergistic effects with other nutrients, such as vitamin D and calcium, to enhance its anti-cancer effects.

UBIAD1 is the enzyme that makes MK-4 inside tissues

Vitamin K2 exists in several forms known as menaquinones, with MK-4 and MK-7 being the most studied. MK-4 is often used in Japan for therapeutic purposes, whereas MK-7 (derived from bacterial fermentation) is widely available as a supplement in Western countries.
For bone and cardiovascular health—and by extension, exploring potential anticancer benefits—doses for MK-7 commonly range from 90 to 200 micrograms per day.
ECM/TCF, Endothelial cell migration/tip cell formation: Click to Expand ⟱
Source: HalifaxProj(inhibit)
Type:
Endothelial cell migration and tip cell formation are critical processes in angiogenesis, the formation of new blood vessels from pre-existing ones. These processes are particularly relevant in the context of cancer, where tumor growth and metastasis often depend on the development of a robust blood supply.
Tumors often secrete pro-angiogenic factors, such as VEGF, to stimulate the formation of new blood vessels. This process allows tumors to obtain the necessary nutrients and oxygen for growth and provides a route for cancer cells to enter the bloodstream and metastasize.
Many tumors overexpress VEGF to stimulate angiogenesis, allowing for increased blood supply to support tumor growth. High levels of VEGF are often associated with poor prognosis in various cancers.
Scientific Papers found: Click to Expand⟱
4770- CoQ10,  VitK2,    Cancer cell stiffening via CoQ10 and UBIAD1 regulates ECM signaling and ferroptosis in breast cancer
- in-vitro, BC, MDA-MB-231
other↑, *antiOx↑, Risk↓, other↑, TumMeta↓, ECM/TCF↓, Akt2↓, Ferroptosis↑, eff↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Ferroptosis↑, 1,  

Cell Death ⓘ

Ferroptosis↑, 1,  

Transcription & Epigenetics ⓘ

other↑, 2,  

Migration ⓘ

Akt2↓, 1,   TumMeta↓, 1,  

Angiogenesis & Vasculature ⓘ

ECM/TCF↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,  

Functional Outcomes ⓘ

Risk↓, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,  
Total Targets: 1

Scientific Paper Hit Count for: ECM/TCF, Endothelial cell migration/tip cell formation
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:168  Target#:99  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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