isoflavones / AR Cancer Research Results

isoFl, isoflavones: Click to Expand ⟱

Features:

Isoflavones occur in many plant species, but are especially high in soybeans.
Major isoflavones in soybean are genistein and daidzein
Supplementation may help lower the risk of hormone-related cancers.

AR, androgen receptor: Click to Expand ⟱

Source: HalifaxProj(suppress signaling);CGL-Driver Genes

Type: Oncogene

Androgens play an important role in the proliferation, differentiation, maintenance and function of the prostate [1]. Intriguingly, they may also be involved in the development and progression of prostate cancer. Androgen deprivation therapy can suppress hormone-naïve prostate cancer, but prostate cancer changes AR and adapts to survive under castration levels of androgen.

The prognostic significance of androgen receptor expression varies widely across different cancer types. In some cancers, high AR expression is associated with poor outcomes, while in others, it may indicate a better prognosis
High expression with poor prognosis is most common.

AR is used as a clinical biomarker for prostate therapy

Scientific Papers found: Click to Expand⟱

122-

CUR,

isoFl,

Combined inhibitory effects of soy isoflavones and curcumin on the production of prostate-specific antigen

Human,

Pca,

LNCaP

 85 participants

PSA↓, AR↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Immune & Inflammatory Signaling ⓘ

PSA↓, 1,

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,

Clinical Biomarkers ⓘ

AR↓, 1, PSA↓, 1,
Total Targets: 4

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: AR, androgen receptor

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells