Tomatine / Bcl-2 Cancer Research Results
Tomatine, Tomatine: Click to Expand ⟱
| Features: |
α-Tomatineis a glycoalkaloid, found in the stems and leaves of tomato plants, and in the fruits at much lower concentrations.
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Bcl-2, B-cell CLL/lymphoma 2: Click to Expand ⟱
| Source: HalifaxProj (inhibit)
CGL-Driver Genes |
| Type: Antiapoptotic
Oncogene |
The proteins of BCL-2 family are classified into three subgroups, i.e., the anti-apoptotic/pro-survival proteins represented by BCL-2 and BCL-XL, the pro-apoptotic proteins represented by BAX and Bak, and the pro-apoptotic BH3-only proteins represented by BAD and BID.
Since the expression of Bcl-2 protein in tumor cells is much higher than that in normal cells, inhibitors targeting it have little effect on normal cells.
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Scientific Papers found: Click to Expand⟱
NF-kB↓, Bcl-2↓, p‑Akt↓, p‑ERK↓, TumCG↓, Apoptosis↑, PCNA↓, BioAv↓,
Showing Research Papers: 1 to 1 of 1
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1
Pathway results for Effect on Cancer / Diseased Cells:
Cell Death ⓘ
p‑Akt↓, 1, Apoptosis↑, 1, Bcl-2↓, 1,
DNA Damage & Repair ⓘ
PCNA↓, 1,
Proliferation, Differentiation & Cell State ⓘ
p‑ERK↓, 1, TumCG↓, 1,
Immune & Inflammatory Signaling ⓘ
NF-kB↓, 1,
Drug Metabolism & Resistance ⓘ
BioAv↓, 1,
Total Targets: 8
Pathway results for Effect on Normal Cells:
Total Targets: 0
Scientific Paper Hit Count for: Bcl-2, B-cell CLL/lymphoma 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:185 Target#:27 State#:% Dir#:1
wNotes=0 sortOrder:rid,rpid
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