Radiotherapy/Radiation / toxicity Cancer Research Results

Rad, Radiotherapy/Radiation: Click to Expand ⟱
Features:
Treatment of disease with radiation, especially by selective irradiation with x-rays or other ionizing radiation and by ingestion of radioisotopes.

Radiosensitizer
Atorvaqone, (mitochondria inhibitor) decrease O2 consumption making more O2 available as a radiosensitizer.
-Hypoxia (low oxygen levels) within tumors is a major cause of resistance to radiotherapy


toxicity, toxicity: Click to Expand ⟱
Source:
Type:
Toxicity
Scientific Papers found: Click to Expand⟱
2022- BBR,  GoldNP,  Rad,    Berberine-loaded Janus gold mesoporous silica nanocarriers for chemo/radio/photothermal therapy of liver cancer and radiation-induced injury inhibition
- in-vitro, Liver, SMMC-7721 cell - in-vitro, Nor, HL7702
*toxicity↓, radioP↑, BioAv↑, AntiTum↑, selectivity↑, eff↑, chemoP↑,
6226- CUR,  Rad,    Analysis of Curcumin as a Radiosensitizer in Cancer Therapy with Serum Survivin Examination: Randomised Control Trial
- Trial, Cerv, NA
survivin↓, RadioS↑, toxicity↓,
7481- H2,  Rad,    Clinical Efficacy of Hydrogen Therapy on Acute Radiation Enteritis and Inflammatory Response in Patients with Cervical Cancer Undergoing Concurrent Chemoradiation Therapy
- Trial, Var, NA
Dose↝, CRP↓, NLR↓, IL6↓, AntiTum∅, *toxicity↓, Inflam↓, radioP↑, *IBI↑, *ROS↓,
7599- HPT,  Rad,    Recent development on hyperthermia: An effective cotreatment improving radiotherapy outcome
- Review, Var, NA
NA↑, RadioS↑, DNArepair↓, Hypoxia↓, EPR↑, LC↑, OS↑, *toxicity↓, Dose↝, BloodF↑, pH↝, Imm↑, HSP70/HSPA5↑,
2064- PB,  Rad,    Phenylbutyrate Attenuates the Expression of Bcl-XL, DNA-PK, Caveolin-1, and VEGF in Prostate Cancer Cells
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145 - in-vitro, Pca, LNCaP
Bcl-xL↓, Cav1↓, VEGF↓, RadioS↑, chemoP↑, HDAC↓, *toxicity↓, Diff↑, Prot↓,
5857- RES,  CAP,  Rad,    Resveratrol and capsaicin as safer radiosensitizers for colorectal cancer compared to 5-fluorouracil
- in-vivo, Var, NA
RadioS↑, hepatoP↝, toxicity↓,

Showing Research Papers: 1 to 6 of 6

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

LC↑, 1,   NA↑, 1,   NLR↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

Cav1↓, 1,  

Cell Death(tgid=5) ⓘ

Bcl-xL↓, 1,   survivin↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Prot↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP70/HSPA5↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNArepair↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Diff↑, 1,   HDAC↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

EPR↑, 1,   Hypoxia↓, 1,   VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CRP↓, 1,   IL6↓, 1,   Imm↑, 1,   Inflam↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↝, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   Dose↝, 2,   eff↑, 1,   RadioS↑, 4,   selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BloodF↑, 1,   CRP↓, 1,   IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiTum↑, 1,   AntiTum∅, 1,   chemoP↑, 2,   hepatoP↝, 1,   OS↑, 1,   radioP↑, 2,   toxicity↓, 2,  
Total Targets: 34

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↓, 1,  

Barriers & Transport(tgid=15) ⓘ

IBI↑, 1,  

Functional Outcomes(tgid=23) ⓘ

toxicity↓, 4,  
Total Targets: 3

Scientific Paper Hit Count for: toxicity, toxicity
6 Radiotherapy/Radiation
1 Berberine
1 Gold NanoParticles
1 Curcumin
1 Hydrogen Gas
1 Hyperthermia
1 Phenylbutyrate
1 Resveratrol
1 Capsaicin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:201  Target#:1025  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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