Radiotherapy/Radiation / Hypoxia Cancer Research Results

Rad, Radiotherapy/Radiation: Click to Expand ⟱
Features:
Treatment of disease with radiation, especially by selective irradiation with x-rays or other ionizing radiation and by ingestion of radioisotopes.

Radiosensitizer
Atorvaqone, (mitochondria inhibitor) decrease O2 consumption making more O2 available as a radiosensitizer.
-Hypoxia (low oxygen levels) within tumors is a major cause of resistance to radiotherapy


Hypoxia, Hypoxia: Click to Expand ⟱
Source: HalifaxProj(reduce)
Type:
Deprived of adequate oxygen supply at the tissue level.
Hypoxia, a condition characterized by insufficient oxygen levels in tissues.
Cancer cells can adapt to hypoxic conditions through various mechanisms. They may activate hypoxia-inducible factors (HIFs), which are transcription factors that help cells respond to low oxygen levels. HIFs promote the expression of genes involved in angiogenesis (formation of new blood vessels), metabolism, and survival.
Tumors with high levels of hypoxia may be more aggressive and less responsive to treatment.
Scientific Papers found: Click to Expand⟱
7649- HPT,  Rad,    A pilot study of the effects of mild systemic heating on human head and neck tumour xenografts: Analysis of tumour perfusion, interstitial fluid pressure, hypoxia and efficacy of radiation therapy
- in-vivo, Laryn, FaDu
Dose↝, BloodF↑, Hypoxia↓, RadioS?,
7599- HPT,  Rad,    Recent development on hyperthermia: An effective cotreatment improving radiotherapy outcome
- Review, Var, NA
NA↑, RadioS↑, DNArepair↓, Hypoxia↓, EPR↑, LC↑, OS↑, *toxicity↓, Dose↝, BloodF↑, pH↝, Imm↑, HSP70/HSPA5↑,
7575- HPT,  Rad,  Chemo,  immuno,    From Localized Mild Hyperthermia to Improved Tumor Oxygenation: Physiological Mechanisms Critically Involved in Oncologic Thermo-Radio-Immunotherapy
RadioS↑, ChemoSen↑, Imm↑, BloodF↑, Hypoxia↓, Dose↝, DNArepair↓, e-pH↓,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

LC↑, 1,   NA↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP70/HSPA5↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNArepair↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

EPR↑, 1,   Hypoxia↓, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Imm↑, 2,  

Cellular Microenvironment(tgid=17) ⓘ

pH↝, 1,   e-pH↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,   Dose↝, 3,   RadioS?, 1,   RadioS↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

BloodF↑, 3,  

Functional Outcomes(tgid=23) ⓘ

OS↑, 1,  
Total Targets: 15

Pathway results for Effect on Normal Cells:


Functional Outcomes(tgid=23) ⓘ

toxicity↓, 1,  
Total Targets: 1

Scientific Paper Hit Count for: Hypoxia, Hypoxia
3 Hyperthermia
3 Radiotherapy/Radiation
1 Chemotherapy
1 immunotherapy
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:201  Target#:151  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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