wortmannin / p62 Cancer Research Results

wortm, wortmannin: Click to Expand ⟱
Features:
Wortmannin is a naturally occurring compound that is known for its inhibitory effects on certain enzymes, particularly phosphatidylinositol 3-kinase (PI3K). It is a fungal metabolite that was first isolated from the fungus Penicillium wortmanni.
Widely used in research as a tool to study the PI3K signaling pathway.
-known as AKT inhibitor

Wortmannin is a potent, naturally derived compound best known for its role as an inhibitor of phosphoinositide 3-kinases (PI3Ks). Unlike vitamins such as vitamin D or vitamin K2, wortmannin is not used as a nutritional supplement or therapeutic agent in the typical clinical setting.

- In cell culture studies, wortmannin is commonly used at concentrations in the low nanomolar range (e.g., 10–100 nM) to inhibit PI3K activity.

- In animal models, the dosing regimen can vary widely depending on the species, route of administration, and study design. Typical experimental doses may range from 0.1 to 1.0 mg/kg, but these studies are primarily investigative and not directed toward therapeutic dosing in humans.
p62, p62/sequestosome 1 (SQSTM1): Click to Expand ⟱
Source:
Type:
A protein that plays a crucial role in various cellular processes, including autophagy, cell signaling, and protein degradation.
p62 is a scaffold protein that interacts with various signaling molecules, including kinases, phosphatases, and ubiquitin ligases. It is also a substrate of autophagy, a process by which cells recycle damaged or dysfunctional organelles and proteins.
p62 is overexpressed in various types of cancer, including breast, lung, colon, and liver cancer.
Its overexpression has been associated with poor prognosis and reduced survival in some cancers.
Scientific Papers found: Click to Expand⟱
312- AgNPs,  wortm,    Inhibition of autophagy enhances the anticancer activity of silver nanoparticles
- vitro+vivo, Cerv, HeLa
APA↑, p62↓, PIK3CA↑, TumVol↓, TumAuto↑, eff↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

PIK3CA↑, 1,  

Autophagy & Lysosomes ⓘ

APA↑, 1,   p62↓, 1,   TumAuto↑, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,  

Functional Outcomes ⓘ

TumVol↓, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: p62, p62/sequestosome 1 (SQSTM1)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:202  Target#:602  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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