temozolomide / Telomerase Cancer Research Results

TMZ, temozolomide: Click to Expand ⟱
Features:
Temozolomide is a chemotherapeutic agent used to treat: GBM
Temozolomide works by interfering with DNA replication: temozolomide is a alkylating agent that adds an alkyl group to the DNA molecule, which interferes with the replication of DNA and ultimately leads to cell death.
Telomerase, Telomerase: Click to Expand ⟱
Source: HalifaxProj (inhibit)
Type:
Telomerase is an enzyme that adds repetitive nucleotide sequences to the ends of chromosomes, known as telomeres. Telomeres protect the chromosome ends from deterioration or fusion with neighboring chromosomes. In most somatic (non-reproductive) cells, telomerase activity is low or absent, leading to gradual shortening of telomeres with each cell division. This shortening is associated with cellular aging and eventual cell senescence or apoptosis (programmed cell death).
Scientific Papers found: Click to Expand⟱
5725- BF,  TMZ,    Bufalin Induces Apoptosis and Improves the Sensitivity of Human Glioma Stem-Like Cells to Temozolamide
- in-vitro, GBM, NA
TumCG↓, TumCP↓, CSCs↓, cl‑Casp3↑, PARP↑, Telomerase↓, eff↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

cl‑Casp3↑, 1,   Telomerase↓, 1,  

DNA Damage & Repair ⓘ

PARP↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 1,   TumCG↓, 1,  

Migration ⓘ

TumCP↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Telomerase, Telomerase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:224  Target#:302  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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