temozolomide / RAD51 Cancer Research Results

TMZ, temozolomide: Click to Expand ⟱
Features:
Temozolomide is a chemotherapeutic agent used to treat: GBM
Temozolomide works by interfering with DNA replication: temozolomide is a alkylating agent that adds an alkyl group to the DNA molecule, which interferes with the replication of DNA and ultimately leads to cell death.
RAD51, RAD51: Click to Expand ⟱
Source:
Type:
RAD51 is a protein that plays a crucial role in the repair of DNA double-strand breaks through homologous recombination (HR). It is a key component of the DNA repair machinery and is essential for maintaining genome stability.
RAD51 expression has been correlated with other biomarkers of DNA repair and genomic instability, such as BRCA1 and BRCA2.
Overexpression: breast, ovarian, prostate, lung
Underexpression: CRC, pancreatic, Hepatocellular, RCC, Melanoma, Thyroid
Scientific Papers found: Click to Expand⟱
571- ART/DHA,  TMZ,    Artesunate enhances the therapeutic response of glioma cells to temozolomide by inhibition of homologous recombination and senescence
- vitro+vivo, GBM, A172 - vitro+vivo, GBM, U87MG
HR↓, RAD51↓, Apoptosis↑, necrosis↑, ROS↑, ChemoSen↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   necrosis↑, 1,  

DNA Damage & Repair ⓘ

HR↓, 1,   RAD51↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: RAD51, RAD51
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:224  Target#:666  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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