temozolomide / HR Cancer Research Results

TMZ, temozolomide: Click to Expand ⟱
Features:
Temozolomide is a chemotherapeutic agent used to treat: GBM
Temozolomide works by interfering with DNA replication: temozolomide is a alkylating agent that adds an alkyl group to the DNA molecule, which interferes with the replication of DNA and ultimately leads to cell death.
HR, Homologous recombination: Click to Expand ⟱
Source:
Type: genes
Homologous recombination (HR) is a type of DNA repair mechanism that plays a crucial role in maintaining genome stability.
HR helps to repair DNA double-strand breaks (DSBs) and other types of DNA damage, maintaining genome stability and preventing mutations that can lead to cancer.
HR genes include: RAD51, BRCA1, BRCA2, RAD52, RAD54, XRCC2, CRcc3
Scientific Papers found: Click to Expand⟱
571- ART/DHA,  TMZ,    Artesunate enhances the therapeutic response of glioma cells to temozolomide by inhibition of homologous recombination and senescence
- vitro+vivo, GBM, A172 - vitro+vivo, GBM, U87MG
HR↓, RAD51↓, Apoptosis↑, necrosis↑, ROS↑, ChemoSen↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   necrosis↑, 1,  

DNA Damage & Repair ⓘ

HR↓, 1,   RAD51↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: HR, Homologous recombination
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:224  Target#:797  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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