Gossypol / TGF-β Cancer Research Results

Gos, Gossypol: Click to Expand ⟱

Features:

Gossypol is a natural compound found in cottonseed, a byproduct of the cotton industry. It has been studied for its potential anti-cancer properties. Research has shown that gossypol can inhibit the growth of various types of cancer cells, including breast, prostate, lung, and colon cancer.

Gossypol's anti-cancer effects are thought to be due to its ability to:

-Inhibit the activity of certain enzymes involved in cancer cell growth and survival
-Induce apoptosis (cell death) in cancer cells
-Inhibit the formation of new blood vessels that feed cancer cells (anti-angiogenesis)
-Modulate the immune system to attack cancer cells

Some studies have also suggested that gossypol may have synergistic effects when combined with other anti-cancer agents, such as chemotherapy and radiation therapy.

TGF-β, transforming growth factor-beta: Click to Expand ⟱

Source: HalifaxProj(inhibit) CGL-CS TCGA

Type:

Human malignancies frequently exhibit mutations in the TGF-β pathway, and overactivation of this system is linked to tumor growth by promoting angiogenesis and inhibiting the innate and adaptive antitumor immune responses.
Anti-inflammatory cytokine.
In normal tissues, TGF-β plays an essential role in cell cycle regulation, immune function, and tissue remodeling.
- In early carcinogenesis, TGF-β typically acts as a tumor suppressor by inhibiting cell proliferation and inducing apoptosis.

In advanced cancers, cells frequently become resistant to the growth-inhibitory effects of TGF-β.
- TGF-β then switches roles and promotes tumor progression by stimulating epithelial-to-mesenchymal transition (EMT), cell invasion, metastasis, and immune evasion.

Non-canonical (Smad-independent) pathways, such as MAPK, PI3K/Akt, and Rho signaling, also contribute to TGF-β-mediated responses.

Elevated levels of TGF-β have been detected in many advanced-stage cancers, including breast, lung, colorectal, pancreatic, and prostate cancers.
- The switch from a tumor-suppressive to a tumor-promoting role is often associated with increased TGF-β production and activation in the tumor microenvironment.

High TGF-β expression or signaling activity is frequently correlated with aggressive disease features, resistance to therapy, increased metastasis, and poorer overall survival in many cancer types.

Scientific Papers found: Click to Expand⟱

941-

Gos,

Rad,

The Lactate Dehydrogenase Inhibitor Gossypol Inhibits Radiation-Induced Pulmonary Fibrosis

in-vivo,

NA,

mice, injection to mice starting at week 4 postirradiation at a dose of 5 mg/kg in 30 μl volume

lactateProd↓, other↓, TGF-β↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Core Metabolism/Glycolysis ⓘ

lactateProd↓, 1,

Transcription & Epigenetics ⓘ

other↓, 1,

Migration ⓘ

TGF-β↓, 1,
Total Targets: 3

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: TGF-β, transforming growth factor-beta

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells