Crocetin / CHOP Cancer Research Results

Cro, Crocetin: Click to Expand ⟱
Features:
Crocetin is a carotenoid pigment found in saffron (Crocus sativus) and has been studied for its potential anti-cancer properties. Research has shown that crocetin may have anti-tumor and anti-proliferative effects, inhibiting the growth of various types of cancer cells.
Crocetin is a carotenoid dicarboxylic acid derived from saffron (Crocus sativus) and is a metabolite of crocin. It is lipophilic and more bioavailable than crocin. In cancer research, crocetin is studied mainly in preclinical models, where it appears to influence apoptosis, inflammation, angiogenesis, and redox signaling. It is not a primary cytotoxic chemotherapeutic, but a signaling and stress-modulating compound.
Mechanistic themes reported:
-NF-κB suppression
-PI3K/AKT pathway modulation
-MAPK signaling effects
-Apoptosis induction (mitochondrial pathway)
-Anti-angiogenic signaling (VEGF reduction)
-Redox modulation (context-dependent antioxidant / pro-oxidant behavior)

Evidence level: predominantly cell culture and animal models.
Reported to modulate glycolytic metabolism and lactate production (model-dependent); not established as a direct LDH enzymatic inhibitor

Crocetin (Cro) — Cancer-Oriented Time-Scale Flagged Pathway Table
Rank Pathway / Axis Cancer / Tumor Context Normal Tissue Context TSF Primary Effect Notes / Interpretation
1 Intrinsic apoptosis (mitochondrial pathway) Bax ↑; Bcl-2 ↓; caspases ↑ (reported) ↔ (less activation) G Cell death signaling Apoptosis induction via mitochondrial membrane disruption is one of the most frequently reported tumor effects.
2 NF-κB inflammatory signaling NF-κB ↓; cytokines/COX-2 ↓ (reported) Inflammation tone ↓ R, G Anti-inflammatory modulation Reduction of inflammatory transcription may contribute to anti-proliferative and anti-invasive effects.
3 PI3K / AKT survival pathway AKT phosphorylation ↓ (reported; model-dependent) ↔ R, G Growth suppression Observed in several tumor cell systems; should be presented as context-dependent.
4 MAPK signaling (ERK / JNK / p38) Stress MAPK modulation (variable direction) ↔ P, R, G Signal reprogramming JNK activation and ERK suppression have been reported in some models; effects vary by cell type.
5 ROS / redox modulation ROS ↑ (pro-apoptotic) or ROS ↓ (antioxidant) depending on dose Oxidative stress ↓ (protective models) P, R, G Redox modulation (biphasic) Crocetin can behave as antioxidant in normal cells and pro-oxidant in tumor contexts at higher concentrations.
6 Cell-cycle arrest G0/G1 or G2/M arrest ↑ (reported) ↔ G Cytostasis Often secondary to survival pathway suppression and stress signaling.
7 Angiogenesis signaling (VEGF) VEGF ↓; angiogenic signaling ↓ (reported) ↔ G Anti-angiogenic support Observed in some in vitro and animal tumor models; typically secondary to NF-κB/AKT changes.
8 Metabolic reprogramming (glycolysis tone) Lactate ↓ (reported; indirect) ↔ R, G Warburg modulation (indirect) No strong evidence for direct LDH enzyme inhibition; effects likely secondary to survival/redox signaling changes.
9 Migration / invasion (MMPs) MMP2/MMP9 ↓; invasion ↓ (reported) ↔ G Anti-invasive phenotype Reported reduction in metastasis markers in certain systems.
10 Chemo-sensitization (adjunct potential) Therapy sensitivity ↑ (reported in some combinations) Normal tissue protection possible G Adjunct modulation May enhance cytotoxic response in some models; data are preclinical.
11 Translation constraint Clinical anti-cancer efficacy not established Generally well tolerated in dietary contexts — Evidence limitation Human oncology data are limited; dosing and bioavailability remain practical considerations.

Time-Scale Flag (TSF): P / R / G

  • P: 0–30 min (early redox and signaling interactions)
  • R: 30 min–3 hr (NF-κB / PI3K / MAPK modulation)
  • G: >3 hr (apoptosis, angiogenesis, and phenotype-level outcomes)
CHOP, GADD153: Click to Expand ⟱
Source:
Type: Protein
GADD153 and CHOP (C/EBP-homologous protein) refer to the same protein. GADD153 stands for "Growth Arrest and DNA Damage-inducible protein 153," while CHOP stands for "C/EBP Homologous Protein."
DDIT3 (DNA Damage Inducible Transcript 3), also known as CHOP (C/EBP Homologous Protein), is a transcription factor that plays a significant role in the cellular response to stress, particularly in the context of the unfolded protein response (UPR) and apoptosis.

CHOP is an important component of the endoplasmic reticulum (ER) stress response. Research has shown that knockdown of CHOP not only enhances tunicamycin-induced autophagy, but also significantly attenuates ER stress-induced apoptosis in human colon cancer cells.
GADD153, also known as CHOP (C/EBP homologous protein), is a transcription factor that plays a significant role in cellular stress responses, particularly in the context of the endoplasmic reticulum (ER) stress response. It is part of the unfolded protein response (UPR), which is activated when there is an accumulation of misfolded proteins in the ER.
Scientific Papers found: Click to Expand⟱
3630- Cro,    Crocin Improves Cognitive Behavior in Rats with Alzheimer's Disease by Regulating Endoplasmic Reticulum Stress and Apoptosis
- in-vivo, AD, NA
*memory↑, *Bcl-2↑, *BAX↓, *Casp3↓, *GRP78/BiP↓, *CHOP↓, *Dose↝,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Cell Death ⓘ

BAX↓, 1,   Bcl-2↑, 1,   Casp3↓, 1,  

Protein Folding & ER Stress ⓘ

CHOP↓, 1,   GRP78/BiP↓, 1,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,  

Functional Outcomes ⓘ

memory↑, 1,  
Total Targets: 7

Scientific Paper Hit Count for: CHOP, GADD153
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:249  Target#:490  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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