probiotics / ZO-1 Cancer Research Results

ProBio, probiotics: Click to Expand ⟱
Features:
Probiotics contain live bacteria the supplements the gastrointestinal flora. (Which can be affected from infection or antibiotics drugs.)
Some studies have suggested that gut microbiota—including Bifidobacterium species—can affect systemic immunity. This is important because the state of the immune system influences the body’s ability to fight cancer and also the response to immunotherapies.
Preclinical investigations have demonstrated that certain Bifidobacterium strains may help improve responses to immune checkpoint inhibitors in animal models.
There has been emerging research looking into discrete strains or formulations of Bifidobacterium longum (sometimes labeled with additional identifiers such as RAPO) that may have unique properties or enhanced effects.
ZO-1, Zonula occludens-1: Click to Expand ⟱
Source:
Type:
ZO-1 (Zonula occludens-1) is a protein that plays a crucial role in the formation and maintenance of tight junctions in epithelial cells. Tight junctions are essential for maintaining the integrity of epithelial barriers and regulating the passage of ions and molecules across the cell membrane.

In the context of cancer, ZO-1 has been implicated in several ways:

1.Loss of ZO-1 expression: Reduced or lost expression observed in various types of cancer.
2.Disruption of tight junctions: Cancer cells often exhibit disrupted tight junctions, which can lead to increased permeability and the loss of epithelial barrier function. ZO-1 is a key component of tight junctions, and its disruption can contribute to the development and progression of cancer.
3.Epithelial-to-mesenchymal transition (EMT): ZO-1 has been shown to play a role in regulating EMT, a process by which epithelial cells acquire a mesenchymal phenotype. EMT is a key event in the development of cancer metastasis, and ZO-1's role in regulating this process is an area of active research.
4.Tumor suppressor function: ZO-1 has been proposed to have tumor suppressor functions, and its loss or downregulation can contribute to the development of cancer. ZO-1's tumor suppressor functions may be related to its ability to regulate cell growth, apoptosis, and cell migration.

ZO-1 generally acts as a tumor suppressor by maintaining epithelial integrity. In many cancers, downregulation or mislocalization of ZO-1 is observed and is associated with a poorer prognosis due to the facilitation of EMT and metastasis.
Scientific Papers found: Click to Expand⟱
8117- LA,  ProBio,    The effects of perioperative probiotic treatment on serum zonulin concentration and subsequent postoperative infectious complications after colorectal cancer surgery: a double-center and double-blind randomized clinical trial
- Trial, CRC, NA
Dose↝, Inf↓, ZO-1↓, other↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Transcription & Epigenetics(tgid=7) ⓘ

other↓, 1,  

Migration(tgid=13) ⓘ

ZO-1↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  

Infection & Microbiome(tgid=24) ⓘ

Inf↓, 1,  
Total Targets: 4

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: ZO-1, Zonula occludens-1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:256  Target#:674  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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