Dichloroacetophenone(2,2-) / Beclin-1 Cancer Research Results

DAP, Dichloroacetophenone(2,2-): Click to Expand ⟱
Features:
2,2-Dichloroacetophenone (DAP) is an acetophenone derivative characterized by the presence of two chlorine atoms on the aromatic ring, typically at the 2‑position relative to the carbonyl group. Its structure and properties differ significantly from compounds like dichloroacetate (DCA).
-DAP may trigger the production of reactive oxygen species (ROS) in cells.
-Increased ROS can lead to cellular damage, which may trigger apoptosis (programmed cell death) in cancer cells that are already under metabolic and oxidative stress.
-Cytotoxic effects via DNA damage.

*** Importantly, 2,2-dichloroacetophenone (DAP) is a much more potent inhibitor of PDK1(Than DCA). It is effective at concentrations in the micromolar (μM) range.
Beclin-1, Beclin-1 (BECN1 gene): Click to Expand ⟱
Source:
Type: Protein Coding gene
Beclin 1, an autophagy and haploinsufficient tumor-suppressor protein, is frequently monoallelically deleted in breast and ovarian cancers. However, the precise mechanisms by which Beclin 1 inhibits tumor growth remain largely unknown.
A key biomarker of autophagy is Beclin-1. Beclin-1 stimulates LC3-I’s lipidation to produce LC3-II, which localizes to the autophagosome membrane to activate the development of autophagosomes.
-BECN1 = the official gene symbol (human gene name)
-Beclin-1 = the protein name encoded by the BECN1 gene
Scientific Papers found: Click to Expand⟱
1871- DAP,    Targeting PDK1 with dichloroacetophenone to inhibit acute myeloid leukemia (AML) cell growth
- in-vitro, AML, U937 - in-vivo, AML, NA
TumCP↓, Apoptosis↑, TumCG↓, PDK1↓, cl‑PARP↑, Bcl-xL↓, Bcl-2↓, Beclin-1↓, ATG3↓, PI3K↓, Akt↓, eff↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

PDK1↓, 1,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↑, 1,   Bcl-2↓, 1,   Bcl-xL↓, 1,  

Autophagy & Lysosomes ⓘ

ATG3↓, 1,   Beclin-1↓, 1,  

DNA Damage & Repair ⓘ

cl‑PARP↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

PI3K↓, 1,   TumCG↓, 1,  

Migration ⓘ

TumCP↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,  
Total Targets: 12

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Beclin-1, Beclin-1 (BECN1 gene)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:289  Target#:30  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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