Xylitol / PFK Cancer Research Results

Xyl, Xylitol: Click to Expand ⟱
Features:
Xylitol is a naturally occurring sugar alcohol commonly found in many fruits and vegetables and is often used as a low-calorie sweetener. While xylitol is best known for its dental health benefits and as a sugar substitute, there is emerging interest in its potential roles in cancer-related research.

-Xylitol may exert antioxidant effects that help reduce oxidative stress.
-Xylitol is well known for its effects on oral bacteria. Since the microbiome can play a role in modulating systemic inflammation and even cancer risk, xylitol’s ability to alter microbial composition might have indirect implications for cancer risk or progression.
PFK, Phosphofructokinase: Click to Expand ⟱
Source:
Type:
PFK (Phosphofructokinase) is a key enzyme in glycolysis, the process by which cells convert glucose into energy. PFK is overexpressed in many types of cancer, and its expression is often associated with poor prognosis.
Mechanisms:
• PFK promotes glycolysis, which is a key metabolic pathway in cancer cells.
• PFK helps to produce energy for cancer cells.
• PFK promotes cell proliferation.

Therapeutic Targeting:
• PFK inhibitors are being developed as a potential therapeutic strategy for cancer treatment.
• Inhibitors of glycolysis, such as 2-deoxyglucose, are being explored as a potential therapeutic strategy for cancer treatment.
Scientific Papers found: Click to Expand⟱
1913- Xyl,    Partial Substitution of Glucose with Xylitol Prolongs Survival and Suppresses Cell Proliferation and Glycolysis of Mice Bearing Orthotopic Xenograft of Oral Cancer
- in-vivo, Oral, NA
TumVol↓, OS↑, PFK↓, toxicity↓, Dose∅, Ki-67↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

PFK↓, 1,  

Migration ⓘ

Ki-67↓, 1,  

Drug Metabolism & Resistance ⓘ

Dose∅, 1,  

Clinical Biomarkers ⓘ

Ki-67↓, 1,  

Functional Outcomes ⓘ

OS↑, 1,   toxicity↓, 1,   TumVol↓, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: PFK, Phosphofructokinase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:298  Target#:945  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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