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| Andrographis — Andrographis (typically Andrographis paniculata, “King of Bitters”) is a bitter medicinal plant whose principal bioactive diterpenoid lactone is andrographolide (with related diterpenoids such as neoandrographolide). It is best classified as a botanical drug / phytochemical mixture (plant extract) with a dominant small-molecule active. Common abbreviation(s): AP (plant), AND (andrographolide). The best-supported pharmacology in humans is anti-inflammatory/immunomodulatory use (e.g., URTI symptom reduction), while oncology relevance is predominantly preclinical, with frequent reporting of NF-κB/STAT3/PI3K-AKT pathway suppression and downstream effects on proliferation, apoptosis, invasion, and angiogenesis. Primary mechanisms (ranked):
Bioavailability / PK relevance: Oral exposure of andrographolide from extracts is highly formulation-dependent and often low; even at high oral regimens used clinically (e.g., extract equivalents targeting ~180–360 mg/day andrographolide), measured plasma concentrations can remain in the low ng/mL range and may show non-linear dose proportionality. This creates a translation gap for many oncology in-vitro concentrations unless delivery is optimized (e.g., solubility enhancement, lipid/polymer carriers, prodrugs). In-vitro vs systemic exposure relevance: Many reported anticancer effects occur at micromolar in-vitro levels that commonly exceed achievable free systemic concentrations after standard oral supplementation; therefore, “direct cytotoxic” interpretations are frequently exposure-limited, while anti-inflammatory signaling modulation may be more plausibly aligned with in-vivo exposures depending on tissue distribution and formulation. Clinical evidence status: Human clinical evidence is strongest for infectious/inflammatory indications (URTI symptom reduction; studied in COVID-19-era settings with mixed outcomes and safety monitoring). For oncology, evidence is primarily preclinical, with limited registered/early clinical exploration and no established standard anticancer indication. "used traditionally for the treatment of array of diseases such as cancer, diabetes, high blood pressure, ulcer, leprosy, bronchitis, skin diseases, flatulence, colic, influenza, dysentery, dyspepsia and malaria for centuries in Asia, America and Africa continents." Andrographolide: – Is a specific diterpenoid lactone and the major active constituent extracted from Andrographis paniculata. – It is responsible for many of the therapeutic effects attributed to the plant, including anti-inflammatory and antioxidant properties. A. Anti-Inflammatory Effects. • Andrographolide has been shown to inhibit the NF-κB pathway, leading to a reduction in the transcription of inflammatory cytokines (e.g., TNF-α, IL-6). • Andrographolide has been reported to cause cell cycle arrest at critical checkpoints (such as G0/G1 or G2/M phase) in some cancer cell models. Andrographis, primarily through its active constituent andrographolide, offers compelling anti-inflammatory, immunomodulatory, pro-apoptotic, and antiproliferative properties. While not a standard anticancer agent, its capacity to modulate key pathways in cellular stress response and inflammation makes it an attractive candidate for complementary research in oncology. Andrographis paniculata, also known as the "King of Bitters," is a plant native to India and Southeast Asia. Its aqueous extract, Andrographis paniculata aqueous extract (APAE), has been studied for its potential anti-cancer properties. • Inhibition of cancer cell growth: APAE has been shown to inhibit the growth of various cancer cell lines, including breast, lung, colon, and prostate cancer cells. • Induction of apoptosis: APAE has been found to induce apoptosis (programmed cell death) in cancer cells, which may help to prevent tumor growth and progression. • Anti-inflammatory effects: APAE has anti-inflammatory properties, which may help to reduce the risk of cancer development and progression. • Antioxidant activity: APAE has antioxidant activity, which may help to protect against oxidative stress and DNA damage. Key compounds:Andrographolide, Neoandrographolide APAE may interact with certain medications, including blood thinners and diabetes medications, and may not be suitable for individuals with certain medical conditions, such as autoimmune disorders. Andrographis (A. paniculata / andrographolide) — ranked mechanistic axes in oncology context
TSF legend: P: 0–30 min; R: 30 min–3 hr; G: >3 hr |
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| Type: HH |
| Gli family zinc-finger transcription factors; GLI1‐dependent target genes (CyclinD1, Bcl‐2, Foxm1) Glioma-associated oncogene homolog 1 (GLI1) is a transcription factor that plays a significant role in the Hedgehog signaling pathway, which is crucial for cell growth, differentiation, and tissue patterning during embryonic development. GLI1 can promote tumor growth and survival by regulating the expression of genes involved in cell proliferation, apoptosis, and angiogenesis. Its overexpression has been associated with aggressive tumor behavior and poor prognosis in several cancer types. ts overexpression is often associated with aggressive tumor behavior, poor prognosis, and resistance to therapy |
| 1353- | And, | Andrographolide Induces Apoptosis and Cell Cycle Arrest through Inhibition of Aberrant Hedgehog Signaling Pathway in Colon Cancer Cells |
| - | in-vitro, | Colon, | HCT116 |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
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