Wogonin / LDHA Cancer Research Results

Wog, Wogonin: Click to Expand ⟱
Features:
Wogonin is a naturally occurring flavonoid typically isolated from Scutellaria baicalensis and has been the focus of cancer research due to its potential anticancer properties.

Pathways:
-PI3K/Akt Pathway Inhibition
-NF-κB Pathway Suppression
-MAPK Pathway Modulation (ERK, JNK, and p38)
-STAT3 Signaling Inhibition:
-Reactive Oxygen Species (ROS) Generation
-Decreases in HKII, PDK1, and LDHA expression
-Suppression of lactate generation, and reduced glucose uptake
LDHA, Lactate dehydrogenase A: Click to Expand ⟱
Source:
Type:
LDHA is a key enzyme that catalyzes the conversion of pyruvate into lactate while regenerating NAD+, essential for glycolysis.
Elevated levels of LDHA have been associated with increased tumor growth and survival. By promoting lactate production, cancer cells can create an acidic microenvironment that may facilitate invasion and metastasis.
Is often upregulated in various types of cancer, including breast, lung, colorectal, and prostate cancers. This upregulation is associated with the metabolic shift that cancer cells undergo to support rapid growth and proliferation.
Measuring the lactate dehydrogenase (LDH) is a useful method for detection of necrosis.
Scientific Papers found: Click to Expand⟱
2301- Wog,    Flavonoids Targeting HIF-1: Implications on Cancer Metabolism
- Review, Var, NA
HK2↓, PDK1↓, LDHA↓, Hif1a↓, PI3K↓, Akt↓, Glycolysis↓, P53↑, GLUT1↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

Glycolysis↓, 1,   HK2↓, 1,   LDHA↓, 1,   PDK1↓, 1,  

Cell Death ⓘ

Akt↓, 1,  

DNA Damage & Repair ⓘ

P53↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

PI3K↓, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1,  

Barriers & Transport ⓘ

GLUT1↓, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: LDHA, Lactate dehydrogenase A
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:314  Target#:175  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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