Wogonin / PDK1 Cancer Research Results

Wog, Wogonin: Click to Expand ⟱
Features:
Wogonin is a naturally occurring flavonoid typically isolated from Scutellaria baicalensis and has been the focus of cancer research due to its potential anticancer properties.

Pathways:
-PI3K/Akt Pathway Inhibition
-NF-κB Pathway Suppression
-MAPK Pathway Modulation (ERK, JNK, and p38)
-STAT3 Signaling Inhibition:
-Reactive Oxygen Species (ROS) Generation
-Decreases in HKII, PDK1, and LDHA expression
-Suppression of lactate generation, and reduced glucose uptake
PDK1, Pyruvate dehydrogenase kinase 1: Click to Expand ⟱
Source:
Type:
PDK1 (3-phosphoinositide-dependent protein kinase-1) (PDPK1) is a serine/threonine kinase that plays a crucial role in various cellular processes, including cell growth, survival, and metabolism. It is a key component of the PI3K/Akt signaling pathway, which is often dysregulated in cancer.
Overexpression or hyperactivation of PDK1 can lead to increased cell proliferation, survival, and resistance to apoptosis, contributing to tumorigenesis.
Inhibitors of PDK1 are being explored in preclinical and clinical studies as a means to disrupt cancer cell growth and survival.
Scientific Papers found: Click to Expand⟱
2301- Wog,    Flavonoids Targeting HIF-1: Implications on Cancer Metabolism
- Review, Var, NA
HK2↓, PDK1↓, LDHA↓, Hif1a↓, PI3K↓, Akt↓, Glycolysis↓, P53↑, GLUT1↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

Glycolysis↓, 1,   HK2↓, 1,   LDHA↓, 1,   PDK1↓, 1,  

Cell Death ⓘ

Akt↓, 1,  

DNA Damage & Repair ⓘ

P53↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

PI3K↓, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1,  

Barriers & Transport ⓘ

GLUT1↓, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: PDK1, Pyruvate dehydrogenase kinase 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:314  Target#:246  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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