Wogonin / MCT4 Cancer Research Results

Wog, Wogonin: Click to Expand ⟱
Features:
Wogonin is a naturally occurring flavonoid typically isolated from Scutellaria baicalensis and has been the focus of cancer research due to its potential anticancer properties.

Pathways:
-PI3K/Akt Pathway Inhibition
-NF-κB Pathway Suppression
-MAPK Pathway Modulation (ERK, JNK, and p38)
-STAT3 Signaling Inhibition:
-Reactive Oxygen Species (ROS) Generation
-Decreases in HKII, PDK1, and LDHA expression
-Suppression of lactate generation, and reduced glucose uptake
MCT4, Monocarboxylate Transporter 4: Click to Expand ⟱
Source:
Type:
MCT4 is a member of the monocarboxylate transporter family, which plays a crucial role in the transport of lactate, pyruvate, and other monocarboxylates across cell membranes. In cancer, MCT4 is often upregulated to support the increased demand for lactate and pyruvate, which are essential for cancer cell metabolism.

High expression of MCT4 is often associated with poor prognosis in various cancers, including breast, lung, colorectal, prostate, pancreatic, ovarian, and glioblastoma.
Scientific Papers found: Click to Expand⟱
2621- Wog,    Natural compounds targeting glycolysis as promising therapeutics for gastric cancer: A review
- Review, Var, NA
Hif1a↓, MCT4↓, LDH↓, lactateProd↓, ECAR↓, TumCP↓, Glycolysis↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

ECAR↓, 1,   Glycolysis↓, 1,   lactateProd↓, 1,   LDH↓, 1,   MCT4↓, 1,  

Migration ⓘ

TumCP↓, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1,  

Clinical Biomarkers ⓘ

LDH↓, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: MCT4, Monocarboxylate Transporter 4
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:314  Target#:949  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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