Worenine / GLUT3 Cancer Research Results

Wor, Worenine: Click to Expand ⟱
Features:
Worenine - Coptis Chinensis (Huanglian in Chinese), a famous traditional herbal medicine used for clearing heat and detoxification.
Worenine is classified as a plant-derived alkaloid.

-Worenine may exert anti-inflammatory and antioxidant effects.
-Production of lactic acid and the uptake and consumption of glucose is significantly inhibited.
-The protein and mRNA levels of GLUT3, HK2, PFK-L, PKM2, and LDHA in HCT116 cells are reduced.
GLUT3, GLUT3: Click to Expand ⟱
Source:
Type:
GLUT3 is a member of the glucose transporter family, which plays a crucial role in glucose uptake and metabolism in cells. In the context of cancer, GLUT3 has been found to be overexpressed in various types of tumors, including brain, breast, colon, and lung cancers.
GLUT3 is overexpressed in cancer cells compared to normal cells. This overexpression is thought to contribute to the increased glucose uptake and metabolism observed in cancer cells.
Scientific Papers found: Click to Expand⟱
2397- Wor,    Phytochemicals targeting glycolysis in colorectal cancer therapy: effects and mechanisms of action
- Review, Var, NA
lactateProd↓, GlucoseCon↓, GLUT3↓, HK2↓, PKM2↓, LDHA↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

GlucoseCon↓, 1,   HK2↓, 1,   lactateProd↓, 1,   LDHA↓, 1,   PKM2↓, 1,  

Barriers & Transport ⓘ

GLUT3↓, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: GLUT3, GLUT3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:318  Target#:928  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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