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| Tumor Treating Fields (TTFields) are a physical, noninvasive treatment modality that uses alternating electric fields in the intermediate frequency range (typically around 100–300 kHz) and low intensity to disrupt cancer cell division. Unlike conventional therapies that target specific molecular pathways with drugs, TTFields work by exerting physical forces on charged and polarizable cellular structures. Nevertheless, several downstream biological effects and pathways have been observed when tumor cells are exposed to TTFields. |
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| Normal cells grow and divide in a regulated manner through the cell cycle, which consists of phases (G1, S, G2, and M). Cancer cells often bypass these regulatory mechanisms, leading to uncontrolled proliferation. This can result from mutations in genes that control the cell cycle, such as oncogenes (which promote cell division) and tumor suppressor genes (which inhibit cell division). |
| 2412- | TTT, | A review of tumor treating fields (TTFields): advancements in clinical applications and mechanistic insights |
| - | Review, | GBM, | NA |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:319 Target#:323 State#:% Dir#:1
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