γ-Tocotrienol / LDHA Cancer Research Results

γ-Toc, γ-Tocotrienol: Click to Expand ⟱
Features:
γ‐Tocotrienol is one of the tocotrienol isomers in the vitamin E family.
γ‐Tocotrienol is naturally found in certain plant oils.

– Notable sources include palm oil, rice bran oil, barley, and annatto.
– Among these, annatto oil is often highlighted as a particularly rich source of tocotrienols (with γ‐tocotrienol being one of the major components).

• Relationship within the Vitamin E Family
– Tocotrienols, including the γ isomer, are one of the two classes of vitamin E compounds (the other being tocopherols).

Pathways:
-Inhibition of NF‑κB Signaling
-downregulate the PI3K/Akt signaling cascade
-inhibit STAT3 activation
-Cell Cycle Arrest
-Antioxidant and Anti‑Inflammatory Effects(reduce reactive oxygen species (ROS) levels)
-may reduce angiogenic factors such as vascular endothelial growth factor (VEGF)

Gamma E Complex (Tocopherols/Tocotrienols) example source
LDHA, Lactate dehydrogenase A: Click to Expand ⟱
Source:
Type:
LDHA is a key enzyme that catalyzes the conversion of pyruvate into lactate while regenerating NAD+, essential for glycolysis.
Elevated levels of LDHA have been associated with increased tumor growth and survival. By promoting lactate production, cancer cells can create an acidic microenvironment that may facilitate invasion and metastasis.
Is often upregulated in various types of cancer, including breast, lung, colorectal, and prostate cancers. This upregulation is associated with the metabolic shift that cancer cells undergo to support rapid growth and proliferation.
Measuring the lactate dehydrogenase (LDH) is a useful method for detection of necrosis.
Scientific Papers found: Click to Expand⟱
2425- γ-Toc,    Anticancer Effects of γ-Tocotrienol Are Associated with a Suppression in Aerobic Glycolysis
- in-vitro, NA, MCF-7 - in-vivo, NA, NA
TumCG↓, GlucoseCon↓, ATP↓, lactateProd↓, Glycolysis↓, HK2↓, PFK↓, PKM2↓, LDHA↓, Akt↓, p‑mTOR↓, cMyc↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics ⓘ

ATP↓, 1,  

Core Metabolism/Glycolysis ⓘ

cMyc↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 1,   HK2↓, 1,   lactateProd↓, 1,   LDHA↓, 1,   PFK↓, 1,   PKM2↓, 1,  

Cell Death ⓘ

Akt↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

p‑mTOR↓, 1,   TumCG↓, 1,  
Total Targets: 12

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: LDHA, Lactate dehydrogenase A
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:321  Target#:175  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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