γ-Tocotrienol / ATP Cancer Research Results

γ-Toc, γ-Tocotrienol: Click to Expand ⟱
Features:
γ‐Tocotrienol is one of the tocotrienol isomers in the vitamin E family.
γ‐Tocotrienol is naturally found in certain plant oils.

– Notable sources include palm oil, rice bran oil, barley, and annatto.
– Among these, annatto oil is often highlighted as a particularly rich source of tocotrienols (with γ‐tocotrienol being one of the major components).

• Relationship within the Vitamin E Family
– Tocotrienols, including the γ isomer, are one of the two classes of vitamin E compounds (the other being tocopherols).

Pathways:
-Inhibition of NF‑κB Signaling
-downregulate the PI3K/Akt signaling cascade
-inhibit STAT3 activation
-Cell Cycle Arrest
-Antioxidant and Anti‑Inflammatory Effects(reduce reactive oxygen species (ROS) levels)
-may reduce angiogenic factors such as vascular endothelial growth factor (VEGF)

Gamma E Complex (Tocopherols/Tocotrienols) example source
ATP, Adenosine triphosphate: Click to Expand ⟱
Source:
Type:
Adenosine triphosphate (ATP) is the source of energy for use and storage at the cellular level.
Cellular ATP levels are critical for cell survival, and several reports have shown that reductions in cellular ATP levels can lead to apoptosis and other types of cell death in cancer cells, depending on the level of depletion.
Adenosine triphosphate (ATP) is one of the main biochemical components of the tumor microenvironment (TME), where it can promote tumor progression or tumor suppression depending on its concentration and on the specific ecto-nucleotidases and receptors expressed by immune and cancer cells.

Cancer cells, unlike normal cells, derive as much as 60% of their ATP from glycolysis via the “Warburg effect”, and the remaining 40% is derived from mitochondrial oxidative phosphorylation.
Scientific Papers found: Click to Expand⟱
2425- γ-Toc,    Anticancer Effects of γ-Tocotrienol Are Associated with a Suppression in Aerobic Glycolysis
- in-vitro, NA, MCF-7 - in-vivo, NA, NA
TumCG↓, GlucoseCon↓, ATP↓, lactateProd↓, Glycolysis↓, HK2↓, PFK↓, PKM2↓, LDHA↓, Akt↓, p‑mTOR↓, cMyc↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics ⓘ

ATP↓, 1,  

Core Metabolism/Glycolysis ⓘ

cMyc↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 1,   HK2↓, 1,   lactateProd↓, 1,   LDHA↓, 1,   PFK↓, 1,   PKM2↓, 1,  

Cell Death ⓘ

Akt↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

p‑mTOR↓, 1,   TumCG↓, 1,  
Total Targets: 12

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: ATP, Adenosine triphosphate
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:321  Target#:21  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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