γ-Tocotrienol / PFK Cancer Research Results

γ-Toc, γ-Tocotrienol: Click to Expand ⟱
Features:
γ‐Tocotrienol is one of the tocotrienol isomers in the vitamin E family.
γ‐Tocotrienol is naturally found in certain plant oils.

– Notable sources include palm oil, rice bran oil, barley, and annatto.
– Among these, annatto oil is often highlighted as a particularly rich source of tocotrienols (with γ‐tocotrienol being one of the major components).

• Relationship within the Vitamin E Family
– Tocotrienols, including the γ isomer, are one of the two classes of vitamin E compounds (the other being tocopherols).

Pathways:
-Inhibition of NF‑κB Signaling
-downregulate the PI3K/Akt signaling cascade
-inhibit STAT3 activation
-Cell Cycle Arrest
-Antioxidant and Anti‑Inflammatory Effects(reduce reactive oxygen species (ROS) levels)
-may reduce angiogenic factors such as vascular endothelial growth factor (VEGF)

Gamma E Complex (Tocopherols/Tocotrienols) example source
PFK, Phosphofructokinase: Click to Expand ⟱
Source:
Type:
PFK (Phosphofructokinase) is a key enzyme in glycolysis, the process by which cells convert glucose into energy. PFK is overexpressed in many types of cancer, and its expression is often associated with poor prognosis.
Mechanisms:
• PFK promotes glycolysis, which is a key metabolic pathway in cancer cells.
• PFK helps to produce energy for cancer cells.
• PFK promotes cell proliferation.

Therapeutic Targeting:
• PFK inhibitors are being developed as a potential therapeutic strategy for cancer treatment.
• Inhibitors of glycolysis, such as 2-deoxyglucose, are being explored as a potential therapeutic strategy for cancer treatment.
Scientific Papers found: Click to Expand⟱
2425- γ-Toc,    Anticancer Effects of γ-Tocotrienol Are Associated with a Suppression in Aerobic Glycolysis
- in-vitro, NA, MCF-7 - in-vivo, NA, NA
TumCG↓, GlucoseCon↓, ATP↓, lactateProd↓, Glycolysis↓, HK2↓, PFK↓, PKM2↓, LDHA↓, Akt↓, p‑mTOR↓, cMyc↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics ⓘ

ATP↓, 1,  

Core Metabolism/Glycolysis ⓘ

cMyc↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 1,   HK2↓, 1,   lactateProd↓, 1,   LDHA↓, 1,   PFK↓, 1,   PKM2↓, 1,  

Cell Death ⓘ

Akt↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

p‑mTOR↓, 1,   TumCG↓, 1,  
Total Targets: 12

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: PFK, Phosphofructokinase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:321  Target#:945  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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