triptolide / lactateProd Cancer Research Results

Trip, triptolide: Click to Expand ⟱
Features:
Triptolide is a diterpenoid triepoxide primarily isolated from the traditional Chinese medicinal plant Tripterygium wilfordii Hook F (commonly known as Thunder God Vine).

Pathways:
-Activation of caspases (key executioners of apoptosis)
-Disruption of mitochondrial membrane potential
-Cell Cycle Arrest
-Suppresses expression of c-myc and mitochondrial hexokinase II (HK-II) in cancer cells
lactateProd, lactate production: Click to Expand ⟱
Source:
Type:
Lactate production has been linked to cancer development and progression. In normal conditions, lactate is produced in cells through a process called glycolysis, which breaks down glucose to generate energy. However, in cancer cells, this process is often upregulated, leading to increased lactate production, even in the presence of oxygen. This phenomenon is known as the Warburg effect.

-Lactate is the end product of glycolysis and induces TGFβ1 upregulation and the acidic microenvironment.
Scientific Papers found: Click to Expand⟱
2454- Trip,    Natural product triptolide induces GSDME-mediated pyroptosis in head and neck cancer through suppressing mitochondrial hexokinase-ΙΙ
- in-vitro, HNSCC, HaCaT - in-vivo, NA, NA
GSDME-N↑, Pyro↑, cMyc↓, HK2↓, BAD↑, BAX↑, Casp3↑, NRF2↓, xCT↓, ROS↑, eff↑, Glycolysis↓, GlucoseCon↓, lactateProd↓, ATP↓, xCT↓, eff↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

NRF2↓, 1,   ROS↑, 1,   xCT↓, 2,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 1,  

Core Metabolism/Glycolysis ⓘ

cMyc↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 1,   HK2↓, 1,   lactateProd↓, 1,  

Cell Death ⓘ

BAD↑, 1,   BAX↑, 1,   Casp3↑, 1,   GSDME-N↑, 1,   Pyro↑, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 2,  
Total Targets: 15

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: lactateProd, lactate production
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:324  Target#:739  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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