metronomic chemo / angioG Cancer Research Results

metroC, metronomic chemo: Click to Expand ⟱
Features:
Metronomic chemotherapy refers to the therapeutic strategy of administering chemotherapeutic drugs at relatively low, minimally toxic doses on a frequent or continuous schedule without extended rest periods. This dosing regimen contrasts with traditional maximum tolerated dose (MTD) chemotherapy, which involves high doses given intermittently with breaks to allow patient recovery.

-The drugs are given in lower doses and more frequently (often daily or multiple times a week)
-Aims to consistently impair tumor growth mechanisms and potentially minimize the chance for cancer cells to recover
-Aims to consistently impair tumor growth mechanisms and potentially minimize the chance for cancer cells to recover
-With a lower dose intensity, patients often experience fewer and less severe side effects
angioG, angiogenesis: Click to Expand ⟱
Source:
Type:
Process through which new blood vessels.
Angiogenesis, the process of new blood vessel formation from pre-existing vessels, plays a crucial role in cancer progression and metastasis. Tumors require a blood supply to grow beyond a certain size and to spread to other parts of the body.
Vascular Endothelial Growth Factor (VEGF): VEGF is one of the most important pro-angiogenic factors. It stimulates endothelial cell proliferation and migration, leading to the formation of new blood vessels. Many tumors overexpress VEGF, which correlates with poor prognosis.
Hypoxia-Inducible Factor (HIF): In response to low oxygen levels (hypoxia), tumors can activate HIF, which in turn promotes the expression of VEGF and other angiogenic factors. This mechanism allows tumors to adapt to their microenvironment and sustain growth.
Scientific Papers found: Click to Expand⟱
2487- metroC,    Metronomic Chemotherapy: Possible Clinical Application in Advanced Hepatocellular Carcinoma
- Review, HCC, NA
toxicity↓, toxicity↓, eff↝, angioG↓, CSCs↓, TSP-1↑, Hif1a↓, VEGF↓, eff↑,
2490- metroC,    Durable complete response of hepatocellular carcinoma after metronomic capecitabine
- Case Report, HCC, NA
angioG↓, TumVol↓, Remission↑,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 1,  

Migration ⓘ

TSP-1↑, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 2,   Hif1a↓, 1,   VEGF↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,   eff↝, 1,  

Functional Outcomes ⓘ

Remission↑, 1,   toxicity↓, 2,   TumVol↓, 1,  
Total Targets: 10

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: angioG, angiogenesis
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:327  Target#:447  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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