mebendazole / α-tubulin Cancer Research Results

meben, mebendazole: Click to Expand ⟱
Features:
Mebendazole—an anthelmintic (anti-parasitic) medication
Mebendazole is traditionally used to treat various parasitic worm infections (helminths).

-Mebendazole has been found to disrupt microtubule formation in cells.
-It might interfere with angiogenesis (the formation of new blood vessels that tumors need to grow)
-Can inhibit the proliferation of various cancer cell lines (such as melanoma, colon cancer, and others)
-May work synergistically with established chemotherapeutic agents.
α-tubulin, α-tubulin: Click to Expand ⟱
Source:
Type:
α-Tubulin is a protein that is a component of microtubules, which are dynamic structures that play a crucial role in various cellular processes, including cell division, cell migration, and intracellular transport.
High α-tubulin expression is associated with poor prognosis, increased tumor size, and metastasis. α-Tubulin expression is also correlated with resistance to chemotherapy and hormone therapy. Generally, high α-tubulin expression is associated with:
      Poor prognosis
      Increased tumor size
      Metastasis
      Resistance to chemotherapy and radiation therapy
      Poor response to treatment

Low α-tubulin expression is associated with:
      Better prognosis
      Smaller tumor size
      Less metastasis
      Better response to chemotherapy and radiation therapy
      Better response to treatment
Scientific Papers found: Click to Expand⟱
2500- meben,    Antiparasitic mebendazole shows survival benefit in 2 preclinical models of glioblastoma multiforme
- in-vitro, GBM, U87MG - in-vivo, GBM, NA
α-tubulin↓, AntiCan↑, TumCG↓, OS↑, VEGF↓, Hif1a↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Proliferation, Differentiation & Cell State ⓘ

TumCG↓, 1,  

Migration ⓘ

α-tubulin↓, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1,   VEGF↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   OS↑, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: α-tubulin, α-tubulin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:331  Target#:933  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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