Galantamine / BChE Cancer Research Results

Gala, Galantamine: Click to Expand ⟱
Features:
Galantamine
FDA approved drug for mild to moderate Alzheimer's Disease
- AChE inhibitor (reversible, competitive)
-May improve memory, cognition, and behavior
BChE, butyrylcholinesterase: Click to Expand ⟱
Source:
Type:
BChE is an enzyme that hydrolyzes choline-based esters. In the brain, it works alongside acetylcholinesterase (AChE) to regulate levels of the neurotransmitter acetylcholine. Since cholinergic deficits are a hallmark of AD, both enzymes have been studied in relation to AD pathology.
- In some AD patients, BChE activity increases relative to AChE.
- Aβ neurotoxicity is amplified when BChE is added to Aβ in tissue culture
Scientific Papers found: Click to Expand⟱
3753- CUR,  Gala,    A Novel Galantamine–Curcumin Hybrid Inhibits Butyrylcholinesterase: A Molecular Dynamics Study
- Study, AD, NA
*BChE↓, *AChE↓, *Ach↑, *cognitive↑, *memory↑, *ROS↓, *Inflam↓, *NF-kB↓, *COX2?,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

ROS↓, 1,  

Transcription & Epigenetics ⓘ

Ach↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2?, 1,   Inflam↓, 1,   NF-kB↓, 1,  

Synaptic & Neurotransmission ⓘ

AChE↓, 1,   BChE↓, 1,  

Functional Outcomes ⓘ

cognitive↑, 1,   memory↑, 1,  
Total Targets: 9

Scientific Paper Hit Count for: BChE, butyrylcholinesterase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:344  Target#:606  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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