hydrogen sulfide / NLRP3 Cancer Research Results

H2S, hydrogen sulfide: Click to Expand ⟱
Features:
Hydrogen sulfide (H₂S), a gaseous signaling molecule, has been implicated in Alzheimer’s disease (AD) pathology with both neuroprotective and neurotoxic roles, depending on concentration, source, and context.
- It was found that the endogenous H2S level in the brain of AD patients was significantly lower than that of normal people.
-A cysteine-rich diet or supplementation with an appropriate amount of N-acetylcysteine is beneficial to the synthesis of H2S in the brain
-Activates Nrf2, upregulates antioxidant genes Reduces oxidative stress, neuroprotective.
-Inhibits NF-κB activation Suppresses inflammatory cytokines like TNF-α, IL-1β
-Reduces Aβ aggregation and toxicity
-Enhances cerebral blood flow
NLRP3, NOD-like receptor pyrin domain-containing protein 3: Click to Expand ⟱
Source:
Type:
NLRP3 (NOD-like receptor pyrin domain-containing protein 3) is a protein that plays a crucial role in the regulation of inflammation and immune responses.
NLRP3 typically has high expression in cancers, with poor prognosis.
For alzheimer's disease:
-NLRP3 is upregulated in Alzheimer's disease (AD)
-NLRP3 is activated in microglia in response to amyloid-β (Aβ) and tau aggregates.
-Promotes tau hyperphosphorylation and spread via inflammation-driven pathways.
Scientific Papers found: Click to Expand⟱
3769- H2S,    Research progress of hydrogen sulfide in Alzheimer's disease from laboratory to hospital: a narrative review
- Review, AD, NA
*APP↓, *Apoptosis↓, *Inflam↓, *antiOx↑, *BP↓, *NLRP3↓, *ROS↓, *Aβ↓, *ER Stress↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   ROS↓, 1,  

Cell Death ⓘ

Apoptosis↓, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↓, 1,  

Migration ⓘ

APP↓, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 1,   NLRP3↓, 1,  

Clinical Biomarkers ⓘ

BP↓, 1,  
Total Targets: 9

Scientific Paper Hit Count for: NLRP3, NOD-like receptor pyrin domain-containing protein 3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:346  Target#:908  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

Home Page