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| Vitamin B3 (Niacin) = nicotinic acid (NA; pharmacologic drug + vitamin) and nicotinamide/niacinamide (NAM; vitamin; NAD+ precursor). Sources: human PK/PD and receptor biology; NAM high-dose AD Phase 2a; GPR109A mechanistic papers. Primary mechanisms (ranked): SEE ALSO NAD Target Forms of Vitamin B3 and Relevance Form Notes Nicotinamide (NAM) Used in most AD and cancer research; does not cause flushing Nicotinic acid More common in cardiovascular use; causes flushing Nicotinamide riboside (NR) NAD⁺ precursor with neuroprotective and anti-aging interest Nicotinamide mononucleotide (NMN) Also boosts NAD⁺; used in aging and cognitive studies Cancers: -Many cancers show depleted NAD⁺ levels. Restoring NAD⁺ via niacin or precursors may decrease growth -Nicotinamide can inhibit sirtuins (SIRT1), which are overexpressed in some cancers -anti-inflammatory -In certain cancers, high NAD⁺ levels may support tumor metabolism (Warburg effect). Alzheimer’s Disease (AD): -reduces ROS -Reduces neuroinflammation: Via SIRT1 activation and NF-κB inhibition. -reduce tau phosphorylation and improve cognitive function. -Boosting NAD⁺ levels may support memory formation Food Niacin (mg per 100g) Notes Tuna (yellowfin, cooked) ~22 mg Among the highest natural sources Chicken breast (roasted) ~14.8 mg Lean, rich source Turkey (light meat) ~12 mg Contains tryptophan, also converted to niacin Beef liver (cooked) ~14 mg Extremely rich in many B vitamins Salmon (cooked) ~8.5 mg Also provides omega-3s Pork (lean, cooked) ~6–8 mg Good source of both niacin and thiamine Vitamin B3 (Niacin: Nicotinic Acid / Nicotinamide) — Cancer vs Normal Pathway Effects
TSF legend: P: 0–30 min (primary/rapid effects) | R: 30 min–3 hr (acute signaling + stress) | G: >3 hr (gene-regulatory adaptation; phenotype outcomes) Vitamin B3 (Nicotinamide-focused) — Alzheimer’s Disease (AD) / Neurons-Glia (Normal-cell context)
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| BACE stands for β-site APP-cleaving enzyme, also known as β-secretase. It plays a central role in the pathogenesis of Alzheimer’s disease by initiating the production of amyloid-β (Aβ) peptides, the primary components of amyloid plaques found in the brains of individuals with AD. -inhibiting BACE1 reduces Aβ production. BACE1 - Beta-Site APP Cleaving Enzyme 1 / β-Secretase 1 Abbreviation: BACE1, β-secretase, β-secretase 1 Type: Aspartyl protease / amyloidogenic APP-processing enzyme Function: BACE1 is a membrane-associated aspartyl protease that performs the initial β-secretase cleavage of amyloid precursor protein (APP). This cleavage generates soluble APPβ and the membrane-bound C99 fragment, which is subsequently cleaved by γ-secretase to produce amyloid-β peptides including Aβ40 and Aβ42. Alzheimer's Disease: ↑ Increased BACE1 expression or enzymatic activity promotes amyloidogenic APP processing and increases amyloid-β production. Elevated BACE1 activity has been reported in Alzheimer's disease and contributes to Aβ accumulation, plaque formation, synaptic dysfunction, and disease progression. BACE1 inhibition reduces Aβ production, although clinical BACE1 inhibitors have been limited by adverse effects related to the enzyme's normal physiological functions. |
| 4033- | VitB3, | Can nicotinamide riboside protect against cognitive impairment? |
| - | in-vivo, | AD, | NA |
| - | in-vivo, | AD, | NA |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:359 Target#:1349 State#:% Dir#:1
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