Oleocanthal / antiOx Cancer Research Results

OLEC, Oleocanthal: Click to Expand ⟱
Features:
Oleocanthal is a phenolic compound found ONLY in extra-virgin olive oil (EVOO).
It has strong anti-inflammatory activity (similar to ibuprofen-like COX inhibition).
In multiple cell and animal studies, it:
-selectively induces lysosomal membrane permeabilization in cancer cells, leading to rapid cell death
-inhibits tumor proliferation and metastasis pathways
-reduces HER2 signaling
-slows colorectal, breast, and prostate cancer progression in models

It has indirect CSC targeting

Not available as a supplement
-it is unstable outside the oil.
-some companies sell high-oleocanthal EVOO


antiOx, anti-oxidant activities: Click to Expand ⟱
Source:
Type:
Various antioxidants such as Nrf2, SODs, catalase, GPxs, PRDXs, and GSTs are altered in different cancers and have been linked to prognosis. Their overexpression can correlate with aggressive tumor behavior and resistance to treatment in many contexts.
Scientific Papers found: Click to Expand⟱
4646- OLEC,    Oleocanthal as a Multifunctional Anti-Cancer Agent: Mechanistic Insights, Advanced Delivery Strategies, and Synergies for Precision Oncology
- Review, Var, NA
BioAv↓, *Inflam↓, *antiOx↓, cMET↓, STAT3↓, TNF-α↓, COX2↓, EMT↓, angioG↓, *GutMicro↝, eff↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Proliferation, Differentiation & Cell State ⓘ

cMET↓, 1,   EMT↓, 1,   STAT3↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   eff↑, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  

Clinical Biomarkers ⓘ

GutMicro↝, 1,  
Total Targets: 3

Scientific Paper Hit Count for: antiOx, anti-oxidant activities
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:377  Target#:1103  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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