Zerumbone / Bcl-2 Cancer Research Results

ZER, Zerumbone: Click to Expand ⟱

Features:

Zerumbone is a sesquiterpene α,β-unsaturated carbonyl compound derived primarily from Zingiber zerumbet (shampoo ginger). It is one of the most intensively studied dietary terpenoids for anticancer activity, with a strong and internally consistent mechanism-of-action profile across multiple cancer types.
Zerumbone induces intrinsic (mitochondrial) apoptosis via:
-↑ ROS generation in cancer cells
-Loss of mitochondrial membrane potential
-↑ Bax / ↓ Bcl-2 and Bcl-xL
-Cytochrome c release
-Caspase-9 → caspase-3 activation

Zerumbone is a potent NF-κB inhibitor

Anti-angiogenic and anti-metastatic effects
-Observed actions include:
-↓ VEGF and HIF-1α
-↓ MMP-2 / MMP-9
-Suppression of EMT markers (N-cadherin, vimentin)
-Reduced migration and invasion

Zerumbone is a redox-bifunctional agent:
In cancer cells:
-↑ ROS beyond survival threshold
-Triggers mitochondrial collapse

In normal cells:
-Activates Nrf2
-Induces phase II detox enzymes (HO-1, NQO1, GST)

This differential redox response explains selective toxicity.
Bioavailability is limited

Bcl-2, B-cell CLL/lymphoma 2: Click to Expand ⟱

Source: HalifaxProj (inhibit) CGL-Driver Genes

Type: Antiapoptotic Oncogene

The proteins of BCL-2 family are classified into three subgroups, i.e., the anti-apoptotic/pro-survival proteins represented by BCL-2 and BCL-XL, the pro-apoptotic proteins represented by BAX and Bak, and the pro-apoptotic BH3-only proteins represented by BAD and BID.
Since the expression of Bcl-2 protein in tumor cells is much higher than that in normal cells, inhibitors targeting it have little effect on normal cells.

Scientific Papers found: Click to Expand⟱

4886-

ZER,

Zerumbone induced apoptosis in liver cancer cells via modulation of Bax/Bcl-2 ratio

in-vitro,

Liver,

HepG2

3.45 ± 0.026 μg/ml.

TumCP↓, Apoptosis↑, BAX↑, Bcl-2↓, *selectivity↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Cell Death ⓘ

Apoptosis↑, 1, BAX↑, 1, Bcl-2↓, 1,

Migration ⓘ

TumCP↓, 1,
Total Targets: 4

Pathway results for Effect on Normal Cells:

Drug Metabolism & Resistance ⓘ

selectivity↑, 1,
Total Targets: 1

Scientific Paper Hit Count for: Bcl-2, B-cell CLL/lymphoma 2

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells