Zerumbone / TumCP Cancer Research Results

ZER, Zerumbone: Click to Expand ⟱
Features:
Zerumbone is a sesquiterpene α,β-unsaturated carbonyl compound derived primarily from Zingiber zerumbet (shampoo ginger). It is one of the most intensively studied dietary terpenoids for anticancer activity, with a strong and internally consistent mechanism-of-action profile across multiple cancer types.
Zerumbone induces intrinsic (mitochondrial) apoptosis via:
-↑ ROS generation in cancer cells
-Loss of mitochondrial membrane potential
-↑ Bax / ↓ Bcl-2 and Bcl-xL
-Cytochrome c release
-Caspase-9 → caspase-3 activation

Zerumbone is a potent NF-κB inhibitor
Anti-angiogenic and anti-metastatic effects
-Observed actions include:
-↓ VEGF and HIF-1α
-↓ MMP-2 / MMP-9
-Suppression of EMT markers (N-cadherin, vimentin)
-Reduced migration and invasion

Zerumbone is a redox-bifunctional agent:
In cancer cells:
-↑ ROS beyond survival threshold
-Triggers mitochondrial collapse

In normal cells:
-Activates Nrf2
-Induces phase II detox enzymes (HO-1, NQO1, GST)

This differential redox response explains selective toxicity.
Bioavailability is limited


TumCP, Tumor Cell proliferation: Click to Expand ⟱
Source:
Type:
Tumor cell proliferation is a key characteristic of cancer. It refers to the rapid and uncontrolled growth of cells that can lead to the formation of tumors.
Scientific Papers found: Click to Expand⟱
4886- ZER,    Zerumbone induced apoptosis in liver cancer cells via modulation of Bax/Bcl-2 ratio
- in-vitro, Liver, HepG2
TumCP↓, Apoptosis↑, BAX↑, Bcl-2↓, *selectivity↑,
4889- ZER,    Zerumbone reduces proliferation of HCT116 colon cancer cells by inhibition of TNF-alpha
- in-vitro, CRC, HCT116
TumCP↓, TNF-α↓, *toxicity↝,
4890- ZER,    Zerumbone, a Southeast Asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis: the alpha,beta-unsaturated carbonyl group is a prerequisite
- in-vitro, Nor, RAW264.7
*iNOS↓, *COX2↓, *EP2↓, TumCP↓, selectivity↑, Apoptosis↑, *chemoP↑, *Inflam↓,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Apoptosis↑, 2,   BAX↑, 1,   Bcl-2↓, 1,  

Migration ⓘ

TumCP↓, 3,  

Immune & Inflammatory Signaling ⓘ

TNF-α↓, 1,  

Drug Metabolism & Resistance ⓘ

selectivity↑, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Cell Death ⓘ

iNOS↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

EP2↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   Inflam↓, 1,  

Drug Metabolism & Resistance ⓘ

selectivity↑, 1,  

Functional Outcomes ⓘ

chemoP↑, 1,   toxicity↝, 1,  
Total Targets: 7

Scientific Paper Hit Count for: TumCP, Tumor Cell proliferation
3 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:384  Target#:327  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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