| Features: |
| Zerumbone is a sesquiterpene α,β-unsaturated carbonyl compound derived primarily from Zingiber zerumbet (shampoo ginger). It is one of the most intensively studied dietary terpenoids for anticancer activity, with a strong and internally consistent mechanism-of-action profile across multiple cancer types.
Zerumbone induces intrinsic (mitochondrial) apoptosis via: -↑ ROS generation in cancer cells -Loss of mitochondrial membrane potential -↑ Bax / ↓ Bcl-2 and Bcl-xL -Cytochrome c release -Caspase-9 → caspase-3 activation Zerumbone is a potent NF-κB inhibitor Anti-angiogenic and anti-metastatic effects -Observed actions include: -↓ VEGF and HIF-1α -↓ MMP-2 / MMP-9 -Suppression of EMT markers (N-cadherin, vimentin) -Reduced migration and invasion Zerumbone is a redox-bifunctional agent: In cancer cells: -↑ ROS beyond survival threshold -Triggers mitochondrial collapse In normal cells: -Activates Nrf2 -Induces phase II detox enzymes (HO-1, NQO1, GST) This differential redox response explains selective toxicity. Bioavailability is limited |
| Source: |
| Type: |
| Vimentin, a major constituent of the intermediate filament family of proteins, is ubiquitously expressed in normal mesenchymal cells and is known to maintain cellular integrity and provide resistance against stress. Vimentin is overexpressed in various epithelial cancers, including prostate cancer, gastrointestinal tumors, tumors of the central nervous system, breast cancer, malignant melanoma, and lung cancer. Vimentin’s overexpression in cancer correlates well with accelerated tumor growth, invasion, and poor prognosis; however, the role of vimentin in cancer progression remains obscure. In many epithelial-derived tumors (carcinomas), elevated Vimentin expression is often observed in cancer cells that have undergone EMT. This upregulation is characteristic of a shift toward a mesenchymal state, which is associated with reduced cell–cell adhesion and increased motility. Vimentin expression is also noted in the tumor stroma, reflecting the presence and activation of mesenchymal cells such as cancer-associated fibroblasts (CAFs). This dual expression can contribute to the remodeling of the tumor microenvironment. The degree of Vimentin expression may vary depending on the tumor type, grade, and stage. More aggressive and advanced tumors tend to show higher levels of Vimentin expression. High Vimentin expression has been correlated with poor clinical outcomes in several cancers, including breast, colorectal, prostate, and lung cancers. Elevated Vimentin levels are typically associated with higher tumor grade, increased invasiveness, enhanced metastatic potential, and a greater risk of recurrence. As a component of the EMT signature, high Vimentin expression can serve as an indicator of a more aggressive tumor phenotype and is often associated with reduced overall survival. - vimentin up-regulation is often used as a marker of EMT in cancer |
| 4888- | ZER, | 5-FU, | Modulation of the tumor microenvironment by zerumbone and 5-fluorouracil in colorectal cancer by target in cancer-associated fibroblasts |
| - | in-vitro, | CRC, | CT26 |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:384 Target#:336 State#:% Dir#:1
wNotes=0 sortOrder:rid,rpid