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| Spermidine : Polyamine (natural small molecule) Sources: Found in foods like wheat germ, soybeans, mushrooms, aged cheese, and fermented foods. Typical dietary intake is ~5–20 mg/day.Top food sources = wheat germ > soybeans > aged cheddar > mushrooms > rice bran/legumes. Ripening / fermentation: especially in aged or fermented foods like cheese, where spermidine and other polyamines can rise during ripening because microbial activity and protein breakdown contribute to amine formation. That is one reason aged cheeses can rank unusually high. Cooking: boiling and grilling significantly reduced polyamine content in many foods, whereas microwave and sous-vide tended to preserve more. Primary Actions: Autophagy induction, mild ROS modulation, epigenetic regulation, and modulation of polyamine metabolism. Pathway Effect of Spermidine Autophagy (ATG genes) ↑ Induction, Beclin-1 activation mTORC1 signaling ↓ Inhibition, promotes catabolic metabolism p53/p21 Modulation via epigenetic changes Polyamine metabolism Supports or stresses proliferating cells ROS / redox balance Mild modulation; sensitizes cancer cells to ROS stressContext-dependent risk: High spermidine levels might support tumor growth in polyamine-addicted cancers; dose, timing, and tumor type matter. Chemo interaction: Generally compatible; not expected to block ROS-dependent therapy at oral doses. Spermidine, a biogenic polyamine that declines along with aging, shows promise in restoring antitumor immunity by enhancing mitochondrial fatty acid oxidation (FAO) Spermidine — Cancer vs Normal Cell Effects
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| Source: CGL-Driver Genes |
| Type: TSG (actually onocogene) |
| A transcriptional co-activator that plays a crucial role in regulating gene expression, cell growth, and differentiation. It is involved in various cellular processes, including the response to signaling pathways and the regulation of the cell cycle. EP300 functions as a tumor suppressor in some contexts, while in others, it may promote oncogenic processes. Its role can depend on the specific type of cancer and the molecular context. High levels may correlate with poor survival outcomes. EP300 is a critical player in cancer biology, with its expression levels serving as potential biomarkers for prognosis in various cancers. Its role in transcriptional regulation and chromatin remodeling underscores its importance in tumorigenesis and cancer progression. EP300 (p300) encodes a histone acetyltransferase (HAT) and transcriptional co-activator. p300 acetylates histones (e.g., H3, H4) and numerous non-histone proteins, loosening chromatin and enabling transcription. It functions as a signal integrator, translating upstream cues (growth factors, stress, hypoxia) into gene expression programs. Key Pathways Modulated by EP300 Pathway / TF EP300 Effect Cancer Consequence p53 Acetylation → activation Tumor suppression (when intact) MYC Co-activation Proliferation, metabolism HIF-1α Co-activation under hypoxia Angiogenesis, survival NF-κB Acetylation Inflammation, survival Hormone receptors (ER/AR) Co-activation Lineage-specific growth |
| 5802- | Sper, | Spermidine reduces cancer-related mortality in humans |
| - | Review, | Var, | NA |
| 5794- | Sper, | Spermidine induces autophagy by inhibiting the acetyltransferase EP300 |
| - | in-vitro, | Nor, | U2OS |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:386 Target#:101 State#:% Dir#:1
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