xanthohumol / TumCP Cancer Research Results

Xan, xanthohumol: Click to Expand ⟱

Features:

Xanthohumol is a prenylated chalcone flavonoid derived from hops (Humulus lupulus).

Commonly described actions include:
-Inflammation suppression: attenuation of NF-κB / STAT3 signaling
-Cell-cycle and survival effects: pro-apoptotic signaling, mitochondrial stress
-Angiogenesis inhibition: reduced VEGF signaling in models
-Metabolic stress modulation: interference with lipid and glucose handling
-Redox effects: antioxidant at low/physiologic exposure; pro-oxidant stress at higher concentrations

Importantly, dose, timing, and cellular context determine which mechanism dominates.

Xanthohumol is best described as chemopreventive or chemo-sensitizing, not chemoprotective:

TumCP, Tumor Cell proliferation: Click to Expand ⟱

Source:

Type:

Tumor cell proliferation is a key characteristic of cancer. It refers to the rapid and uncontrolled growth of cells that can lead to the formation of tumors.

Scientific Papers found: Click to Expand⟱

5014-

PEITC,

Xan,

Combination of xanthohumol and phenethyl isothiocyanate inhibits NF-κB and activates Nrf2 in pancreatic cancer cells

in-vitro,

PC,

NF-kB↓, NRF2↑, GSTP1/GSTπ↑, NQO1↑, SOD↑, TumCP↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress ⓘ

GSTP1/GSTπ↑, 1, NQO1↑, 1, NRF2↑, 1, SOD↑, 1,

Migration ⓘ

TumCP↓, 1,

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 1,
Total Targets: 6

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: TumCP, Tumor Cell proliferation

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells