Sinapic acid / iNOS Cancer Research Results

SA, Sinapic acid: Click to Expand ⟱
Features:

Sinapic Acid - 3,5-Dimethoxy-4-Hydroxycinnamic Acid

Alternative Names: Sinapinic acid, 3,5-dimethoxy-4-hydroxycinnamic acid

Type: Hydroxycinnamic acid / phenolic acid / natural phytochemical

Sources: Widely distributed in fruits, vegetables, cereals, spices, and oilseed crops, with sinapic acid derivatives particularly abundant in plants of the Brassicaceae family.

Function: Sinapic acid is a bioactive phenolic acid with antioxidant, anti-inflammatory, anticancer, neuroprotective, and metal-chelating activities. Reported mechanisms include modulation of oxidative stress, inflammatory signaling, apoptosis, cell proliferation, mitochondrial function, and PI3K/AKT/GSK3β signaling.

Cancer: Preclinical studies demonstrate inhibition of cancer-cell proliferation, induction of apoptosis, suppression of inflammatory and oxidative signaling, and potential sensitization to chemotherapy and radiotherapy. Anticancer activity has been reported across several experimental tumor models.

Alzheimer's Disease: Preclinical studies demonstrate neuroprotective effects including reduced Aβ-associated neuronal injury, oxidative stress, neuroinflammation, and glial activation, with improvements in learning and memory. In APP/PS1 models, sinapic acid has also been reported to reduce Aβ pathology and modulate PI3K/AKT/GSK3β signaling.
iNOS, Inducible nitric oxide synthase: Click to Expand ⟱
Source: HalifaxProj(block)
Type:
An enzyme that produces nitric oxide (NO) in response to inflammatory stimuli.
iNOS can promote tumor growth by enhancing blood flow and nutrient supply to tumors through vasodilation. It may also help cancer cells evade apoptosis (programmed cell death).
Immune Activation: In some contexts, NO produced by iNOS can enhance the immune response against tumors, promoting the activation of immune cells that can target and destroy cancer cells.
Inhibition of Tumor Growth: High levels of NO can induce cytotoxic effects on tumor cells, leading to reduced proliferation and increased apoptosis.
Scientific Papers found: Click to Expand⟱
7830- SA,  MBS,    Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer's Disease: A Review
- Review, AD, NA
*cognitive↑, *memory↑, *antiOx↑, *NeuroI↓, *iNOS↓, *3-NT↓, *Ach↑, *ChAT↑, *Dose↝, *neuroP↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

3-NT↓, 1,   NeuroI↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,  

Cell Death(tgid=5) ⓘ

iNOS↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Ach↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

ChAT↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  

Functional Outcomes(tgid=23) ⓘ

cognitive↑, 1,   memory↑, 1,   neuroP↑, 1,  
Total Targets: 10

Scientific Paper Hit Count for: iNOS, Inducible nitric oxide synthase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:454  Target#:159  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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