| Features: |
| Extracorporeal Shock Wave Therapy - Underwater / Focused Shock Wave Treatment Recommended Abbreviation: ESWT Alternative Names: Extracorporeal shock waves, ESW, shock wave therapy, underwater shock waves, focused shock wave therapy Type: Physical therapy / acoustic-mechanical intervention / experimental anticancer treatment Function: Extracorporeal shock waves are high-pressure acoustic pulses transmitted through a material medium into biological tissue. Shock waves produce rapid mechanical stress, pressure gradients, cavitation-related effects, and transient increases in cell-membrane permeability. Depending on energy and treatment parameters, these effects can alter cellular signaling, drug uptake, vascular responses, apoptosis, and tissue remodeling. Cancer: Preclinical studies demonstrate direct cytotoxic and pro-apoptotic effects in multiple cancer models and increased tumor-cell permeability to anticancer drugs and other therapeutic molecules. Shock waves can enhance the cytotoxic activity of agents including cisplatin, doxorubicin, bleomycin, and paclitaxel and have been investigated for drug delivery and sonodynamic approaches. Direct shock-wave treatment of malignant tumors remains experimental and is not an established standard cancer therapy. Clinical Status: Established extracorporeal shock wave therapy is primarily used for musculoskeletal and rehabilitation indications. Active malignant tissue within the treatment field is generally considered a contraindication for routine clinical ESWT, despite experimental research investigating direct antitumor applications. |
| Source: HalifaxProj (inhibit) |
| Type: |
| A signal protein produced by many cells that stimulates the formation of blood vessels.
Vascular endothelial growth factor (VEGF) is a signal protein that plays a crucial role in angiogenesis, the process by which new blood vessels form from existing ones. This process is vital for normal physiological functions, such as wound healing and the menstrual cycle, but it is also a key factor in the growth and spread of tumors in cancer. Because of its significant role in tumor growth and progression, VEGF has become a target for cancer therapies. Anti-VEGF therapies, such as monoclonal antibodies (e.g., bevacizumab) and small molecule inhibitors, aim to inhibit the action of VEGF, thereby reducing blood supply to tumors and limiting their growth. These therapies have been used in various types of cancer, including colorectal, lung, and breast cancer. |
| 7687- | iod, | ESWT, | Shock Wave Application Increases the Antineoplastic Effect of Molecular Iodine Supplement in Breast Cancer Xenografts |
| - | in-vivo, | BC, | MDA-MB-231 |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:457 Target#:334 State#:% Dir#:1
wNotes=0 sortOrder:rid,rpid