Extracorporeal Shock Wave Therapy / SOX2 Cancer Research Results

ESWT, Extracorporeal Shock Wave Therapy: Click to Expand ⟱
Features:

Extracorporeal Shock Wave Therapy - Underwater / Focused Shock Wave Treatment

Recommended Abbreviation: ESWT

Alternative Names: Extracorporeal shock waves, ESW, shock wave therapy, underwater shock waves, focused shock wave therapy

Type: Physical therapy / acoustic-mechanical intervention / experimental anticancer treatment

Function: Extracorporeal shock waves are high-pressure acoustic pulses transmitted through a material medium into biological tissue. Shock waves produce rapid mechanical stress, pressure gradients, cavitation-related effects, and transient increases in cell-membrane permeability. Depending on energy and treatment parameters, these effects can alter cellular signaling, drug uptake, vascular responses, apoptosis, and tissue remodeling.

Cancer: Preclinical studies demonstrate direct cytotoxic and pro-apoptotic effects in multiple cancer models and increased tumor-cell permeability to anticancer drugs and other therapeutic molecules. Shock waves can enhance the cytotoxic activity of agents including cisplatin, doxorubicin, bleomycin, and paclitaxel and have been investigated for drug delivery and sonodynamic approaches. Direct shock-wave treatment of malignant tumors remains experimental and is not an established standard cancer therapy.

Clinical Status: Established extracorporeal shock wave therapy is primarily used for musculoskeletal and rehabilitation indications. Active malignant tissue within the treatment field is generally considered a contraindication for routine clinical ESWT, despite experimental research investigating direct antitumor applications.
SOX2, SOX2: Click to Expand ⟱
Source:
Type:
SOX2 is a transcription factor that plays a crucial role in the development and maintenance of various cell types, including stem cells and progenitor cells. In the context of cancer, SOX2 has been found to be overexpressed in several types of tumors, including lung, breast, and esophageal cancers.
Overexpressed in: Lung, Breast, Esophageal, Prostate, GBM, CRC.
Scientific Papers found: Click to Expand⟱
7687- iod,  ESWT,    Shock Wave Application Increases the Antineoplastic Effect of Molecular Iodine Supplement in Breast Cancer Xenografts
- in-vivo, BC, MDA-MB-231
antiNeop↑, CSCsMark↓, CD44↓, SOX2↓, HIF-1↓, VEGF↓, Dose↝, Dose↝, EPR↝, PPARγ↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis(tgid=4) ⓘ

PPARγ↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD44↓, 1,   CSCsMark↓, 1,   SOX2↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

EPR↝, 1,   HIF-1↓, 1,   VEGF↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 2,  

Functional Outcomes(tgid=23) ⓘ

antiNeop↑, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: SOX2, SOX2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:457  Target#:656  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

Home Page