Morin / Casp8 Cancer Research Results

MOR, Morin: Click to Expand ⟱

Features:

Morin - 2',3,4',5,7-Pentahydroxyflavone

Recommended Abbreviation: MOR

Type: Flavonol / polyphenolic flavonoid

Sources: Morin occurs naturally in several plants and foods, including members of Morus, Maclura, Artocarpus, and Psidium species.

Function: Morin is a polyphenolic flavonol with antioxidant, anti-inflammatory, metabolic, neuroprotective, and antiproliferative activities. It modulates oxidative stress, mitochondrial function, inflammatory signaling, apoptosis, cell-cycle regulation, and signaling pathways including NF-κB, STAT3, PI3K/AKT, MAPK, and GSK-3β.

Cancer: Preclinical studies show broad anticancer activity. Morin can inhibit proliferation, migration, invasion, epithelial-mesenchymal transition, inflammatory signaling, and angiogenic pathways while promoting apoptosis and cell-cycle arrest. Reported molecular pathways include STAT3, NF-κB, PI3K/AKT, MAPK, Hippo, MMPs, and ROS-related signaling. Human anticancer efficacy has not been established.

Alzheimer's Disease: Preclinical evidence suggests neuroprotective activity. Morin can reduce amyloid-β-induced oxidative stress, mitochondrial dysfunction, calcium dysregulation, and neuronal injury and may inhibit GSK-3β-related signaling relevant to tau hyperphosphorylation and amyloid pathology. Evidence remains experimental, with no established clinical efficacy for Alzheimer's disease.

Casp8, CASP8, caspase 8, apoptosis-related cysteine peptidase: Click to Expand ⟱

Source: CGL-Driver Genes

Type: TSG

Caspase-8 is a unique member of caspases with a dual role in cell death and survival. Caspase-8 expression is often lost in some tumors, but increased in others, indicating a potential pro-survival function in cancer.
Caspase-8 (Casp8) acts as an initiator in cell apoptosis signaling. However, the role of Casp8 in tuning the tumor immune microenvironment remains controversial due to the complicated crosstalk between immune-tolerogenic apoptotic cell death and immunogenic cell death cascades.

Scientific Papers found: Click to Expand⟱

7798-

ISQ,

MOR,

Several targets involved in Alzheimer's disease amyloidogenesis are affected by morin and isoquercitrin

in-vitro,

AD,

*ROS↓, *Casp3↓, *Casp8↓, *Casp9↓, *Aβ↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Total Targets: 0

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

ROS↓, 1,

Cell Death(tgid=5) ⓘ

Casp3↓, 1, Casp8↓, 1, Casp9↓, 1,

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,
Total Targets: 5

Scientific Paper Hit Count for: Casp8, CASP8, caspase 8, apoptosis-related cysteine peptidase

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells