Vitexin / PTP1B Cancer Research Results

VT, Vitexin: Click to Expand ⟱
Features:

Vitexin - Apigenin-8-C-Glucoside

Alternative Names: Apigenin-8-C-glucoside, apigenin-8-C-β-D-glucopyranoside

Type: Flavone C-glycoside / apigenin derivative

Function: Vitexin is a naturally occurring C-glycosylated flavone in which glucose is attached to apigenin at the C-8 position. It exhibits antioxidant, anti-inflammatory, metabolic, cardiovascular, neuroprotective, and antiproliferative activities and can modulate pathways involving NF-κB, Nrf2/HO-1, MAPK, PI3K/AKT, AMPK, HIF-1α, apoptosis, and oxidative stress.

-see also IsoVitexin

Cancer: Preclinical studies indicate antiproliferative, pro-apoptotic, anti-migratory, anti-invasive, and anti-inflammatory effects across multiple cancer models. Reported mechanisms include modulation of PI3K/AKT, MAPK, NF-κB, HIF-1α, ROS, apoptosis, and cell-cycle signaling. Clinical anticancer efficacy has not been established.

Alzheimer's Disease: Preclinical evidence suggests neuroprotective activity through antioxidant and anti-inflammatory effects, reduction of neuronal injury, regulation of oxidative stress and mitochondrial function, and modulation of signaling pathways relevant to cognitive impairment and amyloid-associated neurotoxicity. Clinical efficacy for Alzheimer's disease has not been established.
PTP1B, protein tyrosine phosphatase 1B: Click to Expand ⟱
Source:
Type:
PTP1B (protein tyrosine phosphatase 1B) is a protein that has been linked to the development and progression of certain types of cancer. It plays a role in regulating insulin signaling, and dysregulation of this pathway can contribute to cancer cell growth and survival.
In cancer cells, PTP1B has been shown to promote processes such as epithelial-mesenchymal transition (EMT), which allows cancer cells to become more invasive and metastatic.
PTP1B inhibitors have been shown to reduce tumor growth and metastasis in various cancer models.
In general, PTP1B expression is upregulated in cancer cells, which can contribute to cancer progression and resistance to therapy.
Scientific Papers found: Click to Expand⟱
7891- IVT,  VT,    Effects of C-glycosylation on anti-diabetic, anti-Alzheimer's disease and anti-inflammatory potential of apigenin
- NA, AD, NA
*AntiDiabetic↑, *Inflam↓, *AGEs↓, *AChE↓, *BChE↓, *PTP1B↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Migration(tgid=13) ⓘ

PTP1B↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   BChE↓, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiDiabetic↑, 1,  
Total Targets: 6

Scientific Paper Hit Count for: PTP1B, protein tyrosine phosphatase 1B
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:462  Target#:641  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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