Usnic acid / PD-L1 Cancer Research Results

UsA, Usnic acid: Click to Expand ⟱
Features:

Usnic Acid

Recommended Abbreviation: UA

Type: Natural product / lichen secondary metabolite / dibenzofuran derivative

Source: Usnic acid is a secondary metabolite produced by several lichen genera, including Usnea, Cladonia, Lecanora, and related species. It occurs naturally as (+)- and (-)-usnic acid enantiomers.

Function: Usnic acid exhibits antimicrobial, anti-inflammatory, antioxidant, antiviral, antiparasitic, photoprotective, and experimental anticancer activities. Its biological effects involve mitochondrial function, oxidative stress, apoptosis, inflammatory signaling, and cellular metabolism.

Cancer: Usnic acid has demonstrated preclinical anticancer activity in multiple cancer models, including proliferation ↓, tumor-cell viability ↓, apoptosis ↑, mitochondrial dysfunction ↑, and modulation of oxidative-stress and survival pathways. Its anticancer activity remains predominantly experimental, and toxicity may limit systemic therapeutic use.

Neuroprotection: Experimental studies indicate antioxidant and neuroprotective activity, including Nrf2-associated cytoprotective responses and protection against oxidative and ischemic neuronal injury. Direct evidence for Alzheimer's disease is not sufficiently established to assign a specific Alzheimer's disease direction.

Safety: Usnic acid has a significant hepatotoxicity concern, particularly with systemic or oral exposure at higher doses. Human cases of severe liver injury, including acute liver failure requiring transplantation, have been reported with usnic-acid-containing weight-loss supplements. Mitochondrial dysfunction and oxidative stress are important mechanisms implicated in its hepatotoxicity.
PD-L1, Programmed Death-Ligand 1: Click to Expand ⟱
Source:
Type:
PD-L1 is a protein that plays a crucial role in the regulation of the immune system. PD-L1 helps to prevent the immune system from attacking healthy cells by binding to its receptor, PD-1, on immune cells. However, some cancer cells can exploit this mechanism by expressing high levels of PD-L1, which can help them evade immune detection.
PD-L1 has become a key target for cancer immunotherapy, particularly in the development of checkpoint inhibitors.

PD-1: Upregulated on tumor-infiltrating lymphocytes (TILs), reflecting chronic antigen exposure and an “exhausted” T cell phenotype.
PD-L1 and PD-L2: Frequently overexpressed by many tumor types (e.g., non–small cell lung cancer, melanoma, renal cell carcinoma, head and neck cancers.
Scientific Papers found: Click to Expand⟱
8159- UsA,    Usnic acid suppresses cervical cancer cell proliferation by inhibiting PD-L1 expression and enhancing T-lymphocyte tumor-killing activity
- in-vitro, Cerv, HeLa
STAT3↓, RAS↓, mTOR↓, PD-L1↓, TumCP↓, angioG↓, TumCMig↓, TumCI↓, TumCG↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Proliferation, Differentiation & Cell State(tgid=12) ⓘ

mTOR↓, 1,   RAS↓, 1,   STAT3↓, 1,   TumCG↓, 1,  

Migration(tgid=13) ⓘ

TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

PD-L1↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

PD-L1↓, 1,  
Total Targets: 10

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: PD-L1, Programmed Death-Ligand 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:481  Target#:243  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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