Cyclopamine / Snail Cancer Research Results

CP, Cyclopamine: Click to Expand ⟱
Features:
Cyclopamine is a natural steroidal alkaloid derived from the corn lily, Veratrum californicum, which specifically disrupts the Hh signaling pathway.
Snail, Snail: Click to Expand ⟱
Source:
Type:
Snail gene may show a role in recurrence of breast cancer by downregulating E-cadherin and inducing an epithelial to mesenchymal transition. Snail promotes metastasis of breast cancer cells and overexpression of Snail is a biomarker of poor clinical outcome for patients with breast cancer.
Snail, a repressor of E-cadherin and an inducer of EMT.
Snail (SNAI1):
A transcription factor that plays a key role in the regulation of the epithelial-to-mesenchymal transition (EMT).
It suppresses the expression of epithelial markers (such as E-cadherin) and upregulates mesenchymal markers, facilitating changes in cell adhesion and motility.
EMT Induction:
Snail actively represses genes such as E-cadherin, a protein critical for cell–cell adhesion. Its upregulation leads to a loss of epithelial characteristics and the acquisition of a mesenchymal phenotype, enhancing migratory potential.
Invasion and Metastasis:
Through EMT induction, Snail facilitates tumor cell dissemination and invasion into surrounding tissues, thereby playing a central role in metastasis.

Elevated levels of Snail have been observed in a variety of cancers, including breast, colorectal, pancreatic, and head and neck cancers.
Elevated Snail expression is frequently associated with a worse prognosis, including lower overall survival rates and increased likelihood of metastasis.
Scientific Papers found: Click to Expand⟱
16- CP,  RES,    Resveratrol inhibits the hedgehog signaling pathway and epithelial-mesenchymal transition and suppresses gastric cancer invasion and metastasis
- in-vitro, GC, SGC-7901
HH↓, Gli1↓, EMT↓, N-cadherin↓, E-cadherin↑, Snail↓, TumCI↓, TumMeta↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,   Gli1↓, 1,   HH↓, 1,  

Migration ⓘ

E-cadherin↑, 1,   N-cadherin↓, 1,   Snail↓, 1,   TumCI↓, 1,   TumMeta↓, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Snail, Snail
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:66  Target#:376  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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