Cynanbungeigenin C (CBC) and D (CBD) / Gli1 Cancer Research Results

CBC/D, Cynanbungeigenin C (CBC) and D (CBD): Click to Expand ⟱

Features:

Cynanbungeigenin C (CBC) and D (CBD) from the plant Cynanchum bungei Decne

Gli1, glioma-associated oncogene homolog 1: Click to Expand ⟱

Source:

Type: HH

Gli family zinc-finger transcription factors; GLI1‐dependent target genes (CyclinD1, Bcl‐2, Foxm1)

Glioma-associated oncogene homolog 1 (GLI1) is a transcription factor that plays a significant role in the Hedgehog signaling pathway, which is crucial for cell growth, differentiation, and tissue patterning during embryonic development.
GLI1 can promote tumor growth and survival by regulating the expression of genes involved in cell proliferation, apoptosis, and angiogenesis. Its overexpression has been associated with aggressive tumor behavior and poor prognosis in several cancer types.
ts overexpression is often associated with aggressive tumor behavior, poor prognosis, and resistance to therapy

Scientific Papers found: Click to Expand⟱

17-

CBC/D,

CBC-1 as a Cynanbungeigenin C derivative inhibits the growth of colorectal cancer through targeting Hedgehog pathway component GLI 1

in-vivo,

CRC,

HH↓, Gli1↓, BioAv↓, TumCP↓,

18-

CBC/D,

Cynanbungeigenin C and D, a pair of novel epimers from Cynanchum bungei, suppress hedgehog pathway-dependent medulloblastoma by blocking signaling at the level of Gli

vitro+vivo,

MB,

HH↓, Gli1↓,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:

Proliferation, Differentiation & Cell State ⓘ

Gli1↓, 2, HH↓, 2,

Migration ⓘ

TumCP↓, 1,

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,
Total Targets: 4

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: Gli1, glioma-associated oncogene homolog 1

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells