gefitinib, erlotinib / S6K Cancer Research Results

GB, gefitinib, erlotinib: Click to Expand ⟱
Features:
selectively targeting the mutant proteins in malignant cells.
epidermal growth factor receptor (EGFR) inhibitors (lung cancer)
S6K, S6 kinase: Click to Expand ⟱
Source:
Type: protein
S6K (S6 kinase) is a protein that plays a crucial role in cell growth, proliferation, and survival. It is a downstream target of the mTOR (mechanistic target of rapamycin) signaling pathway, which is a central regulator of cellular metabolism, growth, and division.

Research has shown that S6K is involved in the development and progression of various types of cancer, including breast, lung, prostate, and colon cancer. Overexpression or hyperactivation of S6K has been observed in many cancer types.
Scientific Papers found: Click to Expand⟱
2979- CUR,  GB,    Curcumin overcome primary gefitinib resistance in non-small-cell lung cancer cells through inducing autophagy-related cell death
- in-vitro, Lung, H157 - in-vitro, Lung, H1299
EGFR↓, Sp1/3/4↓, ERK↓, MEK↓, Akt↓, S6K↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics ⓘ

MEK↓, 1,  

Core Metabolism/Glycolysis ⓘ

S6K↓, 1,  

Cell Death ⓘ

Akt↓, 1,  

Kinase & Signal Transduction ⓘ

Sp1/3/4↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↓, 1,  

Angiogenesis & Vasculature ⓘ

EGFR↓, 1,  

Clinical Biomarkers ⓘ

EGFR↓, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: S6K, S6 kinase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:7  Target#:704  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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