Evodiamine / MUC1-C Cancer Research Results

EDM, Evodiamine: Click to Expand ⟱
Features:
Evodiamine is a bioactive alkaloid isolated primarily from the fruit of the traditional Chinese medicinal herb Evodia rutaecarpa. Evodiamine is a natural alkaloid from Evodia rutaecarpa, a traditional Chinese medicine. It has various pharmacological activities, such as anti-inflammatory, anti-cancer, anti-microbial and metabolic regulation, but also shows hepatotoxicity and cardiotoxicity.


MUC1-C, MUC1-C: Click to Expand ⟱
Source:
Type:
MUC1-C is a truncated form of the MUC1 protein that is generated through alternative splicing.
MUC1-C lacks the extracellular domain of MUC1 and is instead localized to the cytoplasm and nucleus. MUC1-C has been shown to have distinct functions from MUC1, including the regulation of cell growth, survival, and transformation.
MUC1-C is often overexpressed in cancer cells and can contribute to oncogenesis by promoting cell proliferation, inhibiting apoptosis, and enhancing metastasis.
Scientific Papers found: Click to Expand⟱
1022- EDM,    Evodiamine suppresses non-small cell lung cancer by elevating CD8+ T cells and downregulating the MUC1-C/PD-L1 axis
- in-vivo, Lung, H1975 - in-vitro, Lung, H1650
TumCG↓, Apoptosis↑, TumCCA↑, PD-L1↓, MUC1-C↓, TumVol↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Apoptosis↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

TumCG↓, 1,  

Migration ⓘ

MUC1-C↓, 1,  

Immune & Inflammatory Signaling ⓘ

PD-L1↓, 1,  

Clinical Biomarkers ⓘ

PD-L1↓, 1,  

Functional Outcomes ⓘ

TumVol↓, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: MUC1-C, MUC1-C
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:76  Target#:971  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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